Diversity of CRISPR-Cas immune systems and molecular machines

Rodolphe Barrangou

doi:10.1186/s13059-015-0816-9

Diversity of CRISPR-Cas immune systems and molecular machines

Rodolphe Barrangou

Food Science

Research output: Contribution to journal › Review article › peer-review

89 Scopus citations

Abstract

Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.

Original language	English (US)
Article number	247
Journal	Genome biology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s13059-015-0816-9
State	Published - Nov 9 2015

All Science Journal Classification (ASJC) codes

Ecology, Evolution, Behavior and Systematics
Genetics
Cell Biology

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10.1186/s13059-015-0816-9

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title = "Diversity of CRISPR-Cas immune systems and molecular machines",

abstract = "Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.",

author = "Rodolphe Barrangou",

note = "Funding Information: The author is supported by start-up funds from North Carolina State University, and the North Carolina Biotechnology Center. The author acknowledges his many colleagues and collaborators in the CRISPR field for their contributions, colourful conversations and insights into these fascinating systems. Publisher Copyright: {\textcopyright} 2015 Barrangou.",

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N2 - Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.

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DO - 10.1186/s13059-015-0816-9

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Diversity of CRISPR-Cas immune systems and molecular machines

Abstract

All Science Journal Classification (ASJC) codes

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