Diverticular disease is associated with benign intra-abdominal cystic disease

Paula F. Wrafter, Tara M. Connelly, Jody S.A. Khan, Brian C. Lucey, Arthur Berg, Walter Koltun, William P. Joyce

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Diverticular disease (DD) and hepatic and renal cysts have been linked with defects in collagen and dysfunctional matrix metalloproteinases. Methods: Consecutive abdominal computed tomography scans between January-July 2015 were prospectively studied to determine a correlation between visceral cysts and DD. Patients with a sigmoid colectomy for pathology other than DD and scans in which DD and/or solid organs were not fully visualized were excluded. A subgroup analysis was performed on youthful DD patients (<55 years of age, n = 32) vs. older controls (>55, n = 213). Results: 238 DD patients (50.8% male) and 369 controls (40.5% male, p =.02) were included. Incidence of visceral cystic disease in DD patients vs. controls was 71.4% vs. 22.5% (p < 0.00001). Renal cysts, present in 53.4% of the DD patients and 18.7% of the controls (p <.00001), were more common than hepatic cysts in both groups. Hepatic cyst prevalence was 8.8 vs. 2.4% (p =.0008). In the subgroup analysis, cystic disease was present in 56.2% of youthful DD patients vs. 29.1% of older controls (p =.004). Conclusions: A significant association between cystic disease and DD was demonstrated overall and in subgroup analysis inclusive of youthful DD patients and older controls. These findings suggest a global defect in connective tissue integrity in DD patients.

Original languageEnglish (US)
Pages (from-to)487-490
Number of pages4
JournalExpert Review of Gastroenterology and Hepatology
Issue number5
StatePublished - May 4 2017

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Diverticular disease is associated with benign intra-abdominal cystic disease'. Together they form a unique fingerprint.

Cite this