DNA adduct of the mitomycin C metabolite 2,7-diaminomitosene is a nontoxic and nonmutagenic DNA lesion in vitro and in vivo

Keyphrases

• 2′-Deoxyguanosine 16%
• Alkylation 33%
• Antitumor Agents 16%
• Bioactivation 16%
• Biological Effects 16%
• Cell-free System 16%
• COS-7 Cells 16%
• Cytosine 16%
• DNA Adducts 100%
• DNA Lesions 100%
• DNA Polymerase 50%
• Escherichia Coli 33%
• Guanine 16%
• Host Cell 16%
• In Situ Formation 16%
• Kidney 16%
• Kidney Cells 16%
• Klenow 33%
• Labelled Primers 16%
• M13 Bacteriophage 16%
• Major Metabolites 16%
• Mammalian Cells 16%
• Mitomycin C 100%
• Monoadducts 33%
• Mutant Frequency 16%
• Mutation Frequency 33%
• Non-mutagenic 100%
• Oligonucleotides 33%
• Phage 16%
• PMS2 16%
• Selective Incorporation 16%
• Spontaneous mutation 16%
• Tumor Cells 16%

Biochemistry, Genetics and Molecular Biology

• Biological Activity 33%
• Cell-Free System 33%
• Crosslinking of DNA 33%
• Deoxyguanosine 33%
• DNA Adduct 100%
• DNA Damage 100%
• DNA Polymerase 100%
• DNA Template 66%
• Escherichia coli 66%
• Metabolite 100%
• Mutation Rate 66%
• Oligonucleotide 66%
• Spontaneous Mutation 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Anticarcinogen 16%
• Bioactivation 16%
• Cytosine 16%
• Deoxyguanosine 16%
• DNA Polymerase 50%
• Escherichia coli 33%
• Guanine 16%
• Mitomycin 100%
• Neoplasm 16%
• Phosphorus 32 16%