DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O⁶-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy

Keyphrases

• Alkyl 100%
• DNA Binding 100%
• O6-methylguanine-DNA Methyltransferase 100%
• Helix-turn-helix Motif 100%
• Cancer Chemotherapy 100%
• Alkylation 50%
• Biologically Relevant 50%
• Active Sites 50%
• Cysteine Residues 50%
• Chemotherapy 50%
• Guanine 50%
• Cancer Prevention 50%
• Helix-turn-helix 50%
• Zinc Ion 50%
• Two-component Domains 50%
• Asparagine 50%
• O6-methylguanine 50%
• Genome Integrity 50%
• DNA Binding Sites 50%
• Minor Groove 50%
• Arginine Finger 50%
• Resistance to Anticancer Therapy 50%
• DNA Conformation 50%
• Direct Damage 50%
• Active Site Motif 50%

Biochemistry, Genetics and Molecular Biology

• DNA Binding 100%
• Helix-Turn-Helix 100%
• Active Site 66%
• Genetics 33%
• Crystal Structure 33%
• Anticancer 33%
• Asparagine 33%
• Zinc Ion 33%
• DNA Binding Site 33%
• DNA Conformation 33%

Chemistry

• Base 100%
• DNA 100%
• Crystal Structure 12%
• Cysteine Residue 12%
• Guanine 12%
• mutagenic 12%
• Arginine 12%
• Asparagine 12%
• Zinc Ion 12%