TY - JOUR
T1 - DNA-directed three-dimensional protein organization
AU - Zhang, Chuan
AU - Tian, Cheng
AU - Guo, Fei
AU - Liu, Zheng
AU - Jiang, Wen
AU - Mao, Chengde
PY - 2012/4/2
Y1 - 2012/4/2
N2 - All bound together: Self-assembled symmetric DNA polyhedra were used to organize proteins in 3D space. Biotin moieties were incorporated into the self-assembled symmetric DNA polyhedra. Upon incubation with streptavidin (STV) protein, an STV protein became bound to each polyhedral face, thus resulting in well-structured DNA polyhedra/STV complexes (see picture, TET=tetrahedron). This strategy was also applied to different 3D DNA nanostructures and different proteins.
AB - All bound together: Self-assembled symmetric DNA polyhedra were used to organize proteins in 3D space. Biotin moieties were incorporated into the self-assembled symmetric DNA polyhedra. Upon incubation with streptavidin (STV) protein, an STV protein became bound to each polyhedral face, thus resulting in well-structured DNA polyhedra/STV complexes (see picture, TET=tetrahedron). This strategy was also applied to different 3D DNA nanostructures and different proteins.
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U2 - 10.1002/anie.201108710
DO - 10.1002/anie.201108710
M3 - Article
C2 - 22374892
AN - SCOPUS:84859228608
SN - 1433-7851
VL - 51
SP - 3382
EP - 3385
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 14
ER -