DNA methylation increases nucleosome compaction and rigidity

John S. Choy, Sijie Wei, Ju Yeon Lee, Song Tan, Steven Chu, Tae Hee Lee

Research output: Contribution to journalArticlepeer-review

208 Scopus citations


(Figure Presented) Cytosine methylation on CpG dinucleotides is an essential epigenetic modification in eukaryotes. How DNA methylation modulates nucleosome structure and dynamics has been a long-standing question. We implemented a single-molecule method to monitor the effects of DNA methylation on the structure and dynamics of mononucleosomes. Our studies show that DNA methylation induces a more compact and rigid nucleosome structure, providing a physical basis for how DNA methylation might contribute to regulating chromatin structure.

Original languageEnglish (US)
Pages (from-to)1782-1783
Number of pages2
JournalJournal of the American Chemical Society
Issue number6
StatePublished - 2010

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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