DNA pooling and dense marker maps: A systematic search for genes for cognitive ability

Linzy Hill, Ian W. Craig, Philip Asherson, David Ball, Thalia Eley, Toshie Ninomiya, Paul J. Fisher, Dragana Turic, Peter McGuffin, Michael J. Owen, Karen Chorney, Michael J. Chorney, Camilla P. Benbow, David Lubinski, Lee A. Thompson, Robert Plomin

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Pooling DNA from subjects within a group and comparing the pooled DNA across groups for a dense map of DNA markers offers a solution to the conundrum that linkage is systematic but not powerful whereas allelic association is powerful but not systematic. We used DNA pooling to screen 66 markers on chromosome 22 in original and replication samples of children of high general cognitive ability (g) and controls of average g. Although none of these markers survived our three-stage screening design (original pooling, replication pooling, individual genotyping), the results of DNA pooling were largely confirmed by individual genotyping. We can therefore exclude associations of major effect size on chromosome 22 for g, a key variable for cognitive neuroscience research on learning and memory.

Original languageEnglish (US)
Pages (from-to)843-848
Number of pages6
Issue number4
StatePublished - Mar 17 1999

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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