Abstract
We have assessed the relationship between DNA synthesis and the differentiation of MEL cells induced by DMSO. Under conditions where the rate of incorporation of 3H-deoxyadenosine into DNA was inhibited by 99%, the rate at which MEL cells become committed to terminal erythroid differentiation was identical to that of a culture treated with inducer alone. We conclude that commitment of MEL cells does not require concomitant DNA synthesis.
Original language | English (US) |
---|---|
Pages (from-to) | 224-230 |
Number of pages | 7 |
Journal | Developmental biology |
Volume | 74 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1980 |
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Developmental Biology
- Cell Biology