Do antioxidants still have a role in the prevention of human cancer?

M. T. Ruffin, C. L. Rock

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Antioxidants are components of diet that are involved in DNA and cell maintenance and repair. Dietary antioxidants include carotenoids, vitamin C, vitamin E, and selenium. Across a variety of cancers, the observational studies have inconsistent results with respect to the relationship shown of specific dietary intake or serum levels of antioxidants and risk of certain cancers. The results of the micronutrient supplement trials clearly do not support a reductionist approach to promoting regression of precancerous lesions or prevention of new cancer, except in a few cancers and specific populations. The ability of the antioxidant micronutrients to influence the risk for tissue injury and for cancer, mediated by their antioxidant activities, remains hypothetical.

Original languageEnglish (US)
Pages (from-to)306-313
Number of pages8
JournalCurrent oncology reports
Issue number4
StatePublished - Jul 2001

All Science Journal Classification (ASJC) codes

  • Oncology


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