Do postliver transplant patients need thromboprophylactic anticoagulation?

Amar Nath Mukerji, Andreas Karachristos, Manoj Maloo, David Johnson, Ashokkumar Jain

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Postoperative thromboprophylactic anticoagulation against Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) is standard of care with current evidence-based guidelines. However, majority of liver transplant (LT) patients have thrombocytopenia and/or prolonged INR before surgery. Studies or guidelines regarding role of prophylactic anticoagulation after LT are lacking. There is a need to balance the risk of thrombosis with significant hemorrhage, implying those needing transfusion or return to OR due to bleeding. We conclude that after LT, anticoagulation is not required routinely for DVT/PE prophylaxis. Rather, it is indicated in specific circumstances, chiefly for prophylaxis of hepatic artery thrombosis or portal vein thrombosis in cases with use of grafts, pediatric cases, small size vessels, Budd Chiari syndrome, amongst others.

Original languageEnglish (US)
Pages (from-to)673-677
Number of pages5
JournalClinical and Applied Thrombosis/Hemostasis
Issue number7
StatePublished - Oct 2014

All Science Journal Classification (ASJC) codes

  • Hematology


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