Docetaxel for malignant mesothelioma: Phase II study of the Eastern Cooperative Oncology Group

Chandra P. Belani, Sudeshna Adak, Seena Aisner, Philip J. Stella, Nathan Levitan, David H. Johnson

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


This Eastern Cooperative Oncology Group phase II trial was conducted to study the effectiveness of docetaxel in patients with malignant mesothelioma. Patients were treated with docetaxel 100 mg/m2 intravenously administered as a 1-hour infusion repeated every 3 weeks. The study accrued a total of 20 patients, 1 of whom was considered ineligible. Of the 19 eligible patients, 1 patient (5%) achieved a partial response, 3 patients (16%) had stable disease, 11 patients (58%) had progressive disease, and 4 patients (21%) were unevaluable. The study was terminated after the first accrual stage because of an insufficient number of complete or partial responses. To date, only 1 patient (with stable disease) has not relapsed. The estimated median survival time is 4 months and the estimated median time to treatment failure is 2.2 months. There were 3 early deaths associated with the treatment regimen: severe gastrointestinal toxicity, hemorrhage, and an acute pulmonary event. Docetaxel as a single agent does not demonstrate evidence of activity in malignant mesothelioma.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalClinical Lung Cancer
Issue number1
StatePublished - Jul 2004

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research


Dive into the research topics of 'Docetaxel for malignant mesothelioma: Phase II study of the Eastern Cooperative Oncology Group'. Together they form a unique fingerprint.

Cite this