TY - JOUR
T1 - Docosahexaenoic acid-enriched canola oil increases adiponectin concentrations
T2 - A randomized crossover controlled intervention trial
AU - Baril-Gravel, L.
AU - Labonté, M. E.
AU - Couture, P.
AU - Vohl, M. C.
AU - Charest, A.
AU - Guay, V.
AU - Jenkins, D. A.
AU - Connelly, P. W.
AU - West, S.
AU - Kris-Etherton, P. M.
AU - Jones, P. J.
AU - Fleming, J. A.
AU - Lamarche, B.
N1 - Funding Information:
We thank all the staff of the clinical unit of investigation and laboratory staff at INAF, RCFFN, Penn State and St-Michael's Hospital for their technical assistance and help in managing this project. We also want to thank the generous contribution of all the study participants. MEL is a recipient of doctoral scholarships from the Canadian Institutes of Health Research and the Fonds de Recherche du Québec – Santé. MCV is Tier 1 Canada Research Chair in Genomics Applied to Nutrition and Health. BL is Chair of Nutrition at Laval University.
Funding Information:
DAJ reported serving on the Scientific Advisory Board of Unilever, Sanitarium Company, California Strawberry Commission, Loblaw Supermarket, Herbal Life International, Nutritional Fundamental for Health, Pacific Health Laboratories, Metagenics, Bayer Consumer Care, Orafti, Dean Foods, Kellogg's, Quaker Oats, Procter & Gamble, Coca-Cola, NuVal Griffin Hospital, Abbott, Pulse Canada, Saskatchewan Pulse Growers, and Canola Council of Canada; receiving honoraria for scientific advice from the Almond Board of California, International Tree Nut Council Nutrition Research and Education Foundation, Barilla, Unilever Canada, Solae, Oldways, Kellogg's, Quaker Oats, Procter & Gamble, Coca-Cola, NuVal Griffin Hospital, Abbott, Canola Council of Canada, Dean Foods, California Strawberry Commission, Haine Celestial, and Alpro Foundation; being on the speakers panel for the Almond Board of California; receiving research grants from Loblaw Brands Ltd., Unilever, Barilla, Almond Board of California, Solae, Haine Celestial, Sanitarium Company, Orafti, International Tree Nut Council, and Peanut Institute; and receiving travel support to meetings from the Almond Board of California, Unilever, Alpro Foundation, and International Tree Nut Council, Canadian Institutes of Health Research, Canada Foundation for Innovation, and the Ontario Research Fund. DAJ receives salary support as a Canada Research Chair from the federal government of Canada and his wife is a director of Glycemic Index Laboratories, Toronto, Ontario, Canada. SW served as a consultant and received travel funding from the Canola Council of Canada. PJJ reported receiving grants from Advanced Foods and Materials Network, Danone, Enzymotec, Unilever, the Canadian Institutes of Health Research and Canada Research Chair Endowment of the Federal Government of Canada. PJJ also serves as President of Nutritional Fundamentals for Health Inc., which markets plant sterols among other nutraceuticals. BL has received research funding from the Dairy Farmers of Canada, Dairy Australia, the Danone Institute and Atrium Innovations and honoraria from Unilever, Danone, and the Dairy Farmers of Canada. BL is Chair in Nutrition and Cardiovascular Health, supported in part by Provigo/Loblaws. LBG, MEL, PC, MCV, AC, VG, PWC, PMKE, JAF have no conflict of interest to declare.
Funding Information:
This study was supported through a grant from the Agri-Food and Agriculture Cluster on Canola in partnership with the Canola Council of Canada, Flax 2015 and Dow AgroSciences. Funding agencies played no role in defining the study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication.
Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background and aims: Little is known about the effect of various dietary fatty acids on pro- and anti-inflammatory processes. We investigated the effect of 5 oils containing various amounts of alpha-linolenic acid (ALA), linoleic acid (LA), oleic acid (OA) and docosahexaenoic acid (DHA) on plasma inflammatory biomarkers and expression levels of key inflammatory genes and transcription factors in whole blood cells. Methods and results: In a randomized, crossover controlled nutrition intervention, 114 adult men and women with abdominal obesity and at least one other criterion for the metabolic syndrome consumed 5 experimental isoenergetic diets for 4 weeks each, separated by 4-week washout periods. Each diet provided 60g/3000kcal of different oils: 1) control corn/safflower oil blend (CornSaff; LA-rich), 2) flax/safflower oil blend (FlaxSaff; ALA-rich), 3) conventional canola oil (Canola; OA-rich), 4) high oleic canola oil (CanolaOleic; highest OA content), 5) DHA-enriched high oleic canola oil (CanolaDHA; OA- and DHA-rich). Gene expression in whole blood cells was assessed in a subset of 62 subjects. CanolaDHA increased plasma adiponectin concentrations compared with the control CornSaff oil treatment (+4.5%, P=0.04) and FlaxSaff (+6.9%, P=0.0008). CanolaDHA also reduced relative expression levels of interleukin (IL). 1B compared with CornSaff and Canola (-11% and -13%, respectively, both P=0.03). High-sensitivity C-reactive protein concentrations were lower after Canola than after FlaxSaff (-17.8%, P=0.047).
AB - Background and aims: Little is known about the effect of various dietary fatty acids on pro- and anti-inflammatory processes. We investigated the effect of 5 oils containing various amounts of alpha-linolenic acid (ALA), linoleic acid (LA), oleic acid (OA) and docosahexaenoic acid (DHA) on plasma inflammatory biomarkers and expression levels of key inflammatory genes and transcription factors in whole blood cells. Methods and results: In a randomized, crossover controlled nutrition intervention, 114 adult men and women with abdominal obesity and at least one other criterion for the metabolic syndrome consumed 5 experimental isoenergetic diets for 4 weeks each, separated by 4-week washout periods. Each diet provided 60g/3000kcal of different oils: 1) control corn/safflower oil blend (CornSaff; LA-rich), 2) flax/safflower oil blend (FlaxSaff; ALA-rich), 3) conventional canola oil (Canola; OA-rich), 4) high oleic canola oil (CanolaOleic; highest OA content), 5) DHA-enriched high oleic canola oil (CanolaDHA; OA- and DHA-rich). Gene expression in whole blood cells was assessed in a subset of 62 subjects. CanolaDHA increased plasma adiponectin concentrations compared with the control CornSaff oil treatment (+4.5%, P=0.04) and FlaxSaff (+6.9%, P=0.0008). CanolaDHA also reduced relative expression levels of interleukin (IL). 1B compared with CornSaff and Canola (-11% and -13%, respectively, both P=0.03). High-sensitivity C-reactive protein concentrations were lower after Canola than after FlaxSaff (-17.8%, P=0.047).
UR - http://www.scopus.com/inward/record.url?scp=84921417567&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921417567&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2014.08.003
DO - 10.1016/j.numecd.2014.08.003
M3 - Article
C2 - 25240692
AN - SCOPUS:84921417567
SN - 0939-4753
VL - 25
SP - 52
EP - 59
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
IS - 1
ER -
