Dopamine markers and general cognitive ability

David Ball, Linzy Hill, Thalia C. Eley, Michael J. Chorney, Karen Chorney, Lee A. Thompson, Douglas K. Detterman, Camilla Benbow, David Lubinski, Michael Owen, Peter McGuffin, Robert Plomin

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


BECAUSE general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.

Original languageEnglish (US)
Pages (from-to)347-349
Number of pages3
Issue number2
StatePublished - Jan 26 1998

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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