Abstract
BECAUSE general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.
Original language | English (US) |
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Pages (from-to) | 347-349 |
Number of pages | 3 |
Journal | Neuroreport |
Volume | 9 |
Issue number | 2 |
DOIs | |
State | Published - Jan 26 1998 |
All Science Journal Classification (ASJC) codes
- General Neuroscience