TY - JOUR
T1 - Dopamine receptor-interacting proteins
T2 - The Ca2+ connection in dopamine signaling
AU - Bergson, Clare
AU - Levenson, Robert
AU - Goldman-Rakic, Patricia S.
AU - Lidow, Michael S.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Abnormal activity of the dopamine system has been implicated in several psychiatric and neurological illnesses; however, lack of knowledge about the precise sites of dopamine dysfunction has compromised our ability to improve the efficacy and safety of dopamine-related drugs used in treatment modalities. Recent work suggests that dopamine transmission is regulated via the concerted efforts of a cohort of cytoskeletal, adaptor and signaling proteins called dopamine receptor-interacting proteins (DRIPs). The discovery that two DRIPs, calcyon and neuronal Ca2+ sensor 1 (NCS-1), are upregulated in schizophrenia highlights the possibility that altered protein interactions and defects in Ca2+ homeostasis might contribute to abnormalities in the brain dopamine system in neuropsychiatric diseases.
AB - Abnormal activity of the dopamine system has been implicated in several psychiatric and neurological illnesses; however, lack of knowledge about the precise sites of dopamine dysfunction has compromised our ability to improve the efficacy and safety of dopamine-related drugs used in treatment modalities. Recent work suggests that dopamine transmission is regulated via the concerted efforts of a cohort of cytoskeletal, adaptor and signaling proteins called dopamine receptor-interacting proteins (DRIPs). The discovery that two DRIPs, calcyon and neuronal Ca2+ sensor 1 (NCS-1), are upregulated in schizophrenia highlights the possibility that altered protein interactions and defects in Ca2+ homeostasis might contribute to abnormalities in the brain dopamine system in neuropsychiatric diseases.
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U2 - 10.1016/S0165-6147(03)00232-3
DO - 10.1016/S0165-6147(03)00232-3
M3 - Review article
C2 - 12967774
AN - SCOPUS:0042880916
SN - 0165-6147
VL - 24
SP - 486
EP - 492
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 9
ER -