Dopamine receptor-interacting proteins: The Ca2+ connection in dopamine signaling

Clare Bergson, Robert Levenson, Patricia S. Goldman-Rakic, Michael S. Lidow

Research output: Contribution to journalReview articlepeer-review

160 Scopus citations


Abnormal activity of the dopamine system has been implicated in several psychiatric and neurological illnesses; however, lack of knowledge about the precise sites of dopamine dysfunction has compromised our ability to improve the efficacy and safety of dopamine-related drugs used in treatment modalities. Recent work suggests that dopamine transmission is regulated via the concerted efforts of a cohort of cytoskeletal, adaptor and signaling proteins called dopamine receptor-interacting proteins (DRIPs). The discovery that two DRIPs, calcyon and neuronal Ca2+ sensor 1 (NCS-1), are upregulated in schizophrenia highlights the possibility that altered protein interactions and defects in Ca2+ homeostasis might contribute to abnormalities in the brain dopamine system in neuropsychiatric diseases.

Original languageEnglish (US)
Pages (from-to)486-492
Number of pages7
JournalTrends in Pharmacological Sciences
Issue number9
StatePublished - Sep 1 2003

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology


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