Abstract
The cell line PTC-1113A was established from a metastasizing recurrent papillary thyroid cancer. The cell line was growing as monolayer and showed a complex karyotype with chromosome numbers ranging from 30 to 140/metaphase. A proportion of metaphases contained double minutes and/or pulverized chromosomes. Extrachromosomal DNA seemed to originate from a B-group chromosome. A chromosome 4 painting probe hybridized (FISH) with the chromosome 4 library detected a translocation chromosome and a pulverized chromosome originating from chromosome 4, PTC-1113A is, to our knowledge, the single papillary thyroid cancer cell line demonstrating evidence of gene amplification.
Original language | English (US) |
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Pages (from-to) | 70-74 |
Number of pages | 5 |
Journal | Cancer Genetics and Cytogenetics |
Volume | 90 |
Issue number | 1 |
DOIs | |
State | Published - Aug 1996 |
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Genetics
- Cancer Research