Double minutes in the papillary thyroid cancer cell line PTC-1113A

Marille E. Herrmann, Peter A. Lalley, Linea L. Rydstedt, Eckart Meese, Charles H. Lang, Naji N. Abumrad, Ute M. Moll, Gary B. Talpos

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The cell line PTC-1113A was established from a metastasizing recurrent papillary thyroid cancer. The cell line was growing as monolayer and showed a complex karyotype with chromosome numbers ranging from 30 to 140/metaphase. A proportion of metaphases contained double minutes and/or pulverized chromosomes. Extrachromosomal DNA seemed to originate from a B-group chromosome. A chromosome 4 painting probe hybridized (FISH) with the chromosome 4 library detected a translocation chromosome and a pulverized chromosome originating from chromosome 4, PTC-1113A is, to our knowledge, the single papillary thyroid cancer cell line demonstrating evidence of gene amplification.

Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalCancer Genetics and Cytogenetics
Issue number1
StatePublished - Aug 1996

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research


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