Double minutes in the papillary thyroid cancer cell line PTC-1113A

Marille E. Herrmann; Peter A. Lalley; Linea L. Rydstedt; Eckart Meese; Charles H. Lang; Naji N. Abumrad; Ute M. Moll; Gary B. Talpos

doi:10.1016/0165-4608(96)00048-9

Double minutes in the papillary thyroid cancer cell line PTC-1113A

Marille E. Herrmann, Peter A. Lalley, Linea L. Rydstedt, Eckart Meese, Charles H. Lang, Naji N. Abumrad, Ute M. Moll, Gary B. Talpos

Department of Cellular and Molecular Physiology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The cell line PTC-1113A was established from a metastasizing recurrent papillary thyroid cancer. The cell line was growing as monolayer and showed a complex karyotype with chromosome numbers ranging from 30 to 140/metaphase. A proportion of metaphases contained double minutes and/or pulverized chromosomes. Extrachromosomal DNA seemed to originate from a B-group chromosome. A chromosome 4 painting probe hybridized (FISH) with the chromosome 4 library detected a translocation chromosome and a pulverized chromosome originating from chromosome 4, PTC-1113A is, to our knowledge, the single papillary thyroid cancer cell line demonstrating evidence of gene amplification.

Original language	English (US)
Pages (from-to)	70-74
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(96)00048-9
State	Published - Aug 1996

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Cancer Research

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10.1016/0165-4608(96)00048-9

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title = "Double minutes in the papillary thyroid cancer cell line PTC-1113A",

abstract = "The cell line PTC-1113A was established from a metastasizing recurrent papillary thyroid cancer. The cell line was growing as monolayer and showed a complex karyotype with chromosome numbers ranging from 30 to 140/metaphase. A proportion of metaphases contained double minutes and/or pulverized chromosomes. Extrachromosomal DNA seemed to originate from a B-group chromosome. A chromosome 4 painting probe hybridized (FISH) with the chromosome 4 library detected a translocation chromosome and a pulverized chromosome originating from chromosome 4, PTC-1113A is, to our knowledge, the single papillary thyroid cancer cell line demonstrating evidence of gene amplification.",

author = "Herrmann, {Marille E.} and Lalley, {Peter A.} and Rydstedt, {Linea L.} and Eckart Meese and Lang, {Charles H.} and Abumrad, {Naji N.} and Moll, {Ute M.} and Talpos, {Gary B.}",

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T1 - Double minutes in the papillary thyroid cancer cell line PTC-1113A

AU - Herrmann, Marille E.

AU - Lalley, Peter A.

AU - Rydstedt, Linea L.

AU - Meese, Eckart

AU - Lang, Charles H.

AU - Abumrad, Naji N.

AU - Moll, Ute M.

AU - Talpos, Gary B.

PY - 1996/8

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N2 - The cell line PTC-1113A was established from a metastasizing recurrent papillary thyroid cancer. The cell line was growing as monolayer and showed a complex karyotype with chromosome numbers ranging from 30 to 140/metaphase. A proportion of metaphases contained double minutes and/or pulverized chromosomes. Extrachromosomal DNA seemed to originate from a B-group chromosome. A chromosome 4 painting probe hybridized (FISH) with the chromosome 4 library detected a translocation chromosome and a pulverized chromosome originating from chromosome 4, PTC-1113A is, to our knowledge, the single papillary thyroid cancer cell line demonstrating evidence of gene amplification.

AB - The cell line PTC-1113A was established from a metastasizing recurrent papillary thyroid cancer. The cell line was growing as monolayer and showed a complex karyotype with chromosome numbers ranging from 30 to 140/metaphase. A proportion of metaphases contained double minutes and/or pulverized chromosomes. Extrachromosomal DNA seemed to originate from a B-group chromosome. A chromosome 4 painting probe hybridized (FISH) with the chromosome 4 library detected a translocation chromosome and a pulverized chromosome originating from chromosome 4, PTC-1113A is, to our knowledge, the single papillary thyroid cancer cell line demonstrating evidence of gene amplification.

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Double minutes in the papillary thyroid cancer cell line PTC-1113A

Abstract

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