Dragmacidin e synthesis studies. Preparation of a model heptacyclic core structure

Ken S. Feldman; Paiboon Ngernmeesri

doi:10.1021/ol1018008

Dragmacidin e synthesis studies. Preparation of a model heptacyclic core structure

Ken S. Feldman, Paiboon Ngernmeesri

Chemistry

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The conversion of a cycloheptannelated indole platform into the heptacyclic core structure of dragmacidin E proceeded over nine steps. Key sequences include a cyclocondensation to form an intermediate dihydropyrazinone ring and the conversion of a cyclic urea into the cyclic guanidine of the target.

Original language	English (US)
Pages (from-to)	4502-4505
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	20
DOIs	https://doi.org/10.1021/ol1018008
State	Published - Oct 15 2010

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol1018008

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abstract = "The conversion of a cycloheptannelated indole platform into the heptacyclic core structure of dragmacidin E proceeded over nine steps. Key sequences include a cyclocondensation to form an intermediate dihydropyrazinone ring and the conversion of a cyclic urea into the cyclic guanidine of the target.",

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N2 - The conversion of a cycloheptannelated indole platform into the heptacyclic core structure of dragmacidin E proceeded over nine steps. Key sequences include a cyclocondensation to form an intermediate dihydropyrazinone ring and the conversion of a cyclic urea into the cyclic guanidine of the target.

AB - The conversion of a cycloheptannelated indole platform into the heptacyclic core structure of dragmacidin E proceeded over nine steps. Key sequences include a cyclocondensation to form an intermediate dihydropyrazinone ring and the conversion of a cyclic urea into the cyclic guanidine of the target.

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M3 - Article

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EP - 4505

JO - Organic Letters

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IS - 20

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Dragmacidin e synthesis studies. Preparation of a model heptacyclic core structure

Abstract

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