TY - JOUR
T1 - Drawn-on-Skin Sensors from Fully Biocompatible Inks toward High-Quality Electrophysiology
AU - Patel, Shubham
AU - Ershad, Faheem
AU - Lee, Jimmy
AU - Chacon-Alberty, Lourdes
AU - Wang, Yifan
AU - Morales-Garza, Marco A.
AU - Haces-Garcia, Arturo
AU - Jang, Seonmin
AU - Gonzalez, Lei
AU - Contreras, Luis
AU - Agarwal, Aman
AU - Rao, Zhoulyu
AU - Liu, Grace
AU - Efimov, Igor R.
AU - Zhang, Yu Shrike
AU - Zhao, Min
AU - Isseroff, Roslyn Rivkah
AU - Karim, Alamgir
AU - Elgalad, Abdelmotagaly
AU - Zhu, Weihang
AU - Wu, Xiaoyang
AU - Yu, Cunjiang
N1 - Publisher Copyright:
© 2022 Wiley-VCH GmbH.
PY - 2022/9/8
Y1 - 2022/9/8
N2 - The need to develop wearable devices for personal health monitoring, diagnostics, and therapy has inspired the production of innovative on-demand, customizable technologies. Several of these technologies enable printing of raw electronic materials directly onto biological organs and tissues. However, few of them have been thoroughly investigated for biocompatibility of the raw materials on the cellular, tissue, and organ levels or with different cell types. In addition, highly accurate multiday in vivo monitoring using such on-demand, in situ fabricated devices has yet to be done. Presented herein is the first fully biocompatible, on-skin fabricated electronics for multiple cell types and tissues that can capture electrophysiological signals with high fidelity. While also demonstrating improved mechanical and electrical properties, the drawn-on-skin ink retains its properties under various writing conditions, which minimizes the variation in electrical performance. Furthermore, the drawn-on-skin ink shows excellent biocompatibility with cardiomyocytes, neurons, mice skin tissue, and human skin. The high signal-to-noise ratios of the electrophysiological signals recorded with the DoS sensor over multiple days demonstrate its potential for personalized, long-term, and accurate electrophysiological health monitoring.
AB - The need to develop wearable devices for personal health monitoring, diagnostics, and therapy has inspired the production of innovative on-demand, customizable technologies. Several of these technologies enable printing of raw electronic materials directly onto biological organs and tissues. However, few of them have been thoroughly investigated for biocompatibility of the raw materials on the cellular, tissue, and organ levels or with different cell types. In addition, highly accurate multiday in vivo monitoring using such on-demand, in situ fabricated devices has yet to be done. Presented herein is the first fully biocompatible, on-skin fabricated electronics for multiple cell types and tissues that can capture electrophysiological signals with high fidelity. While also demonstrating improved mechanical and electrical properties, the drawn-on-skin ink retains its properties under various writing conditions, which minimizes the variation in electrical performance. Furthermore, the drawn-on-skin ink shows excellent biocompatibility with cardiomyocytes, neurons, mice skin tissue, and human skin. The high signal-to-noise ratios of the electrophysiological signals recorded with the DoS sensor over multiple days demonstrate its potential for personalized, long-term, and accurate electrophysiological health monitoring.
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U2 - 10.1002/smll.202107099
DO - 10.1002/smll.202107099
M3 - Article
C2 - 36073141
AN - SCOPUS:85137459248
SN - 1613-6810
VL - 18
JO - Small
JF - Small
IS - 36
M1 - 2107099
ER -