DRESS is a Mess: A Case of Cross Reactivity Between Lacosamide and Lamotrigine

Elizabeth Packard; Ricci Kalayanamitra; Zainab Shahid; Ravi Patel; Justin Roy; Ashok Maddukari; Andrew Groff; Hyma Polimera; Reshma Golamari; Nitasa Sahu; Rama Vunnam; Dhirisha Bhatt; Rohit Jain

DRESS is a Mess: A Case of Cross Reactivity Between Lacosamide and Lamotrigine

Elizabeth Packard
, Ricci Kalayanamitra
, Zainab Shahid
, Ravi Patel
, Justin Roy
, Ashok Maddukari
, Andrew Groff
, Hyma Polimera
, Reshma Golamari
, Nitasa Sahu
, Rama Vunnam
, Dhirisha Bhatt
, Rohit Jain

Research output: Contribution to journal › Article › peer-review

Abstract

Drug reaction with eosinophilia with systemic symptoms (DRESS) syndrome is a rare drug reaction often presenting with both cutaneous manifestations and potentially life-threatening internal organ involvement. The precise incidence of DRESS is still unclear as it is easily missed due to its highly variable clinical presentation. However, with an expected mortality rate of approximately 10 percent, it is important for clinicians to be familiar with pharmacologic etiologies commonly implicated in the pathogenesis. We present a case of DRESS syndrome attributed to cross-reactivity between two commonly used anticonvulsants- lacosamide and lamotrigine.

Original language	English (US)
Pages (from-to)	324-328
Number of pages	5
Journal	South Dakota medicine : the journal of the South Dakota State Medical Association
Volume	74
Issue number	7
State	Published - Jul 1 2021

All Science Journal Classification (ASJC) codes

General Medicine

Cite this

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title = "DRESS is a Mess: A Case of Cross Reactivity Between Lacosamide and Lamotrigine",

abstract = "Drug reaction with eosinophilia with systemic symptoms (DRESS) syndrome is a rare drug reaction often presenting with both cutaneous manifestations and potentially life-threatening internal organ involvement. The precise incidence of DRESS is still unclear as it is easily missed due to its highly variable clinical presentation. However, with an expected mortality rate of approximately 10 percent, it is important for clinicians to be familiar with pharmacologic etiologies commonly implicated in the pathogenesis. We present a case of DRESS syndrome attributed to cross-reactivity between two commonly used anticonvulsants- lacosamide and lamotrigine.",

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T2 - A Case of Cross Reactivity Between Lacosamide and Lamotrigine

AU - Packard, Elizabeth

AU - Kalayanamitra, Ricci

AU - Shahid, Zainab

AU - Patel, Ravi

AU - Roy, Justin

AU - Maddukari, Ashok

AU - Groff, Andrew

AU - Polimera, Hyma

AU - Golamari, Reshma

AU - Sahu, Nitasa

AU - Vunnam, Rama

AU - Bhatt, Dhirisha

AU - Jain, Rohit

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Drug reaction with eosinophilia with systemic symptoms (DRESS) syndrome is a rare drug reaction often presenting with both cutaneous manifestations and potentially life-threatening internal organ involvement. The precise incidence of DRESS is still unclear as it is easily missed due to its highly variable clinical presentation. However, with an expected mortality rate of approximately 10 percent, it is important for clinicians to be familiar with pharmacologic etiologies commonly implicated in the pathogenesis. We present a case of DRESS syndrome attributed to cross-reactivity between two commonly used anticonvulsants- lacosamide and lamotrigine.

AB - Drug reaction with eosinophilia with systemic symptoms (DRESS) syndrome is a rare drug reaction often presenting with both cutaneous manifestations and potentially life-threatening internal organ involvement. The precise incidence of DRESS is still unclear as it is easily missed due to its highly variable clinical presentation. However, with an expected mortality rate of approximately 10 percent, it is important for clinicians to be familiar with pharmacologic etiologies commonly implicated in the pathogenesis. We present a case of DRESS syndrome attributed to cross-reactivity between two commonly used anticonvulsants- lacosamide and lamotrigine.

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SN - 0038-3317

VL - 74

SP - 324

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JO - South Dakota medicine : the journal of the South Dakota State Medical Association

JF - South Dakota medicine : the journal of the South Dakota State Medical Association

IS - 7

ER -

DRESS is a Mess: A Case of Cross Reactivity Between Lacosamide and Lamotrigine

Abstract

All Science Journal Classification (ASJC) codes

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