Drinking a lot is good for dendritic cells

Research output: Contribution to journalReview articlepeer-review

132 Scopus citations


Macropinocytosis is the actin-dependent formation of large vesicles, which allow the internalization of large quantities of fluid-phase solute. In the majority of cells examined, an exogenous stimulus is required to induce the initiation of this endocyticq4 pathway. However, dendritic cells are thought to constitutively macropinocytose large quantities of exogenous solute as part of their sentinel function. In this review we discuss the evidence that dendritic cells macropinocytose exogenous solute and subsequently present antigenic peptides derived from internalized material to T cells. In addition, we put these data into the context of immune surveillance in vivo.

Original languageEnglish (US)
Pages (from-to)443-451
Number of pages9
Issue number4
StatePublished - Apr 2006

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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