TY - JOUR
T1 - Drug-induced liver injury in the elderly
AU - Stine, Jonathan G.
AU - Sateesh, Praveen
AU - Lewis, James H.
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2013/1
Y1 - 2013/1
N2 - Historically, the elderly have been considered to be at increased risk for drug-induced liver injury (DILI). Animal studies have demonstrated changes in hepatic physiology that affect drug metabolism in the aging liver; however, there is no evidence that this leads to any appreciable deterioration of liver function in healthy older humans. Updated data from international DILI registries give us pause to consider whether the elderly are truly at increased risk to develop hepatic injury. Instead, hepatotoxicity in the elderly appears to be more a function of drug exposure, polypharmacy and drug-drug interactions. Isoniazid and benoxaprofen are the only two agents with a well-studied correlation between increasing age and risk of DILI. Nevertheless, given the increasing proportion of patients over age 65 in the U.S. and abroad, the influence of age on the risk of DILI is the focus of this review.
AB - Historically, the elderly have been considered to be at increased risk for drug-induced liver injury (DILI). Animal studies have demonstrated changes in hepatic physiology that affect drug metabolism in the aging liver; however, there is no evidence that this leads to any appreciable deterioration of liver function in healthy older humans. Updated data from international DILI registries give us pause to consider whether the elderly are truly at increased risk to develop hepatic injury. Instead, hepatotoxicity in the elderly appears to be more a function of drug exposure, polypharmacy and drug-drug interactions. Isoniazid and benoxaprofen are the only two agents with a well-studied correlation between increasing age and risk of DILI. Nevertheless, given the increasing proportion of patients over age 65 in the U.S. and abroad, the influence of age on the risk of DILI is the focus of this review.
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U2 - 10.1007/s11894-012-0299-8
DO - 10.1007/s11894-012-0299-8
M3 - Article
C2 - 23250699
AN - SCOPUS:84871153968
SN - 1522-8037
VL - 15
JO - Current gastroenterology reports
JF - Current gastroenterology reports
IS - 1
M1 - 299
ER -