Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects

Keyphrases

• Extracellular Signal-regulated Kinase 100%
• Antitumor Effect 100%
• Nuclear Translocation 100%
• Gene Induction 100%
• Forkhead Box O3 (FOXO3) 100%
• AKT Pathway 100%
• Therapeutic Agents 50%
• Small Molecules 50%
• Clinical Trials 50%
• Recombinant 50%
• Tumor 50%
• Microenvironment 50%
• Gene Transcription 50%
• Blood-brain Barrier 50%
• Tumor Suppressor 50%
• Tumor Cells 50%
• Antitumor Activity 50%
• Anticancer Therapy 50%
• Orally Active 50%
• P53-independent 50%
• Serum Half-life 50%
• Biodistribution 50%
• Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) 50%

Biochemistry, Genetics and Molecular Biology

• Protein Kinase B 100%
• Extracellular Signal-Regulated Kinases 100%
• TRAIL 100%
• Gene Induction 100%
• Small Molecule 8%
• Promoter Region 8%
• Genetic Transcription 8%
• Clinical Trial 8%
• Anticancer 8%
• Tumor Suppressor Protein 8%
• P53 8%
• Upregulation 8%
• Antineoplastic Activity 8%
• Blood Brain Barrier 8%
• Plasma Half Life 8%
• Biodistribution 8%
• Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand 50%