Dynamic gene expression of Lin-28 during embryonic development in mouse and chicken

Shigetoshi Yokoyama, Megumi Hashimoto, Hirohito Shimizu, Hiroe Ueno-Kudoh, Kenta Uchibe, Ichiro Kimura, Hiroshi Asahara

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


The Caenorhabditis elegans heterochronic gene lin-28 regulates developmental timing in the nematode trunk. We report the dynamic expression patterns of Lin-28 homologues in mouse and chick embryos. Whole mount in situ hybridization revealed specific and intriguing expression patterns of Lin-28 in the developing mouse and chick limb bud. Mouse Lin-28 expression was detected in both the forelimb and hindlimb at E9.5, but disappeared from the forelimb at E10.5, and finally from the forelimb and hindlimb at E11.5. Chicken Lin-28, which was first detected in the limb primordium at stage 15/16, was also downregulated as the stage proceeded. The amino acid sequences of mouse and chicken Lin-28 genes are highly conserved and the similar expression patterns of Lin-28 during limb development in mouse and chicken suggest that this heterochronic gene is also conserved during vertebrate limb development.

Original languageEnglish (US)
Pages (from-to)155-160
Number of pages6
JournalGene Expression Patterns
Issue number3
StatePublished - Feb 2008

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Developmental Biology


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