Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation

Casey Cruse, Timothy Walter Moural, Fang Zhu

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Insects have evolved several intricate defense mechanisms to adapt to their chemical environment. Due to their versatile capabilities in hydrolytic biotransformation, insect carboxyl/cholinesterases (CCEs) play vital roles in the development of pesticide resistance, facilitating the adaptation of insects to their host plants, and manipulating insect behaviors through the olfaction system. CCEs confer insecticide resistance through the mechanisms of qualitative or quantitative changes of CCE-mediated enhanced metabolism or target-site insensitivity, and may contribute to the host plant adaptation. CCEs represent the first odorant-degrading enzymes (ODEs) discovered to degrade insect pheromones and plant odors and remain the most promising ODE candidates. Here, we summarize insect CCE classification, currently characterized insect CCE protein structure characteristics, and the dynamic roles of insect CCEs in chemical adaptation.

Original languageEnglish (US)
Article number194
Issue number2
StatePublished - Feb 2023

All Science Journal Classification (ASJC) codes

  • Insect Science

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