Abstract
Background: Nucleosome assembly mediated by histone chaperones and DNA methylation play important roles in gene regulation. Results: Dynamics of nucleosome assembly with and without CpG methylation was investigated. Conclusion: CpG methylation increases the efficiency of nucleosome assembly. Significance: CpG methylation accelerates nucleosome formation that may facilitate gene packaging in chromatin.
Original language | English (US) |
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Pages (from-to) | 4291-4303 |
Number of pages | 13 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 7 |
DOIs | |
State | Published - Feb 13 2015 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology