Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production

Keyphrases

• Dysregulation 100%
• Protein Production 100%
• Supply Chain 100%
• TAR DNA-binding Protein 43 (TDP-43) 100%
• RNA-binding Protein 33%
• Nervous System 33%
• Amyotrophic Lateral Sclerosis 33%
• RNA Processing 33%
• Frontotemporal Dementia 33%
• Gene Expression 16%
• Delocalization 16%
• Age-dependent 16%
• Etiology 16%
• Cell-derived 16%
• Gene Regulation 16%
• Synaptic Connections 16%
• Neurodegenerative Diseases 16%
• Early Events 16%
• Related Disorders 16%
• Multiple Aspects 16%
• Local Control 16%
• Common Denominator 16%
• Patient-derived 16%
• Cultured Cells 16%
• Dementia Diseases 16%
• Pathogenic Role 16%
• Developmental Cues 16%
• Disease Pathogenesis 16%
• Translation Mechanism 16%
• Causative mutation 16%
• Cytoplasmic Aggregates 16%

Neuroscience

• Gene Expression 100%
• Nervous System 100%
• Amyotrophic Lateral Sclerosis 100%
• RNA Processing 100%
• Frontotemporal Dementia 100%
• RNA-binding Protein 100%
• Neurodegenerative Disorder 50%

Medicine and Dentistry

• TDP 43 Proteinopathy 100%
• Transactive Response Dna Binding Protein-43 100%
• Gene Expression 50%
• Amyotrophic Lateral Sclerosis 50%
• RNA Binding Protein 50%
• Frontotemporal Lobar Degeneration 50%
• Nervous System 50%
• Lifespan 25%
• Neurodegenerative Disorder 25%
• Disease 25%
• Diseases 25%