Abstract
Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short elimination half-lives, when tolerance had begun to develop. Early morning insomnia may be a variant of rebound insomnia and therefore specific to benzodiazepines, or it may occur with any rapidly eliminated sedative-hypnotic agent.
Original language | English (US) |
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Pages (from-to) | 95-97 |
Number of pages | 3 |
Journal | Science |
Volume | 220 |
Issue number | 4592 |
DOIs | |
State | Published - 1983 |
All Science Journal Classification (ASJC) codes
- General