Early morning insomnia with rapidly eliminated benzodiazepines

Anthony Kales, Constantin R. Soldatos, Edward O. Bixler, Joyce D. Kales

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short elimination half-lives, when tolerance had begun to develop. Early morning insomnia may be a variant of rebound insomnia and therefore specific to benzodiazepines, or it may occur with any rapidly eliminated sedative-hypnotic agent.

Original languageEnglish (US)
Pages (from-to)95-97
Number of pages3
Issue number4592
StatePublished - 1983

All Science Journal Classification (ASJC) codes

  • General


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