TY - JOUR
T1 - Early recognition and treatment of severe sepsis and septic shock in CAP
AU - Jaehne, Anja Kathrin
AU - Jayaprakash, Namita
AU - Hurst, Gina
AU - Moore, Steven
AU - Harrison, Michael F.
AU - Rivers, Emanuel P.
PY - 2014/3
Y1 - 2014/3
N2 - Community-acquired pneumonia is one of the most common causes of severe sepsis and septic shock, accounting for up to 45% of cases admitted to hospitals. Early identification and illness severity stratification followed by early intervention using a bundled treatment approach have been shown to improve outcomes. This includes blood cultures before antibiotics, fluid resuscitation with 30 mL kg-1 body weight to target a mean arterial blood pressure of at least 65 mmHg, central venous pressure between 8 and 12 mmHg, and a central venous oxygen saturation of 70% within 6 h of diagnosis. In addition, early and appropriate introduction of ventilator assistance not only improves gas exchange, it further reduces the imbalance between oxygen delivery and utilisation. The mortality reduction is also accompanied by a decrease in duration of mechanical ventilation, vasopressor use, and intensive care unit and hospital length of stay.
AB - Community-acquired pneumonia is one of the most common causes of severe sepsis and septic shock, accounting for up to 45% of cases admitted to hospitals. Early identification and illness severity stratification followed by early intervention using a bundled treatment approach have been shown to improve outcomes. This includes blood cultures before antibiotics, fluid resuscitation with 30 mL kg-1 body weight to target a mean arterial blood pressure of at least 65 mmHg, central venous pressure between 8 and 12 mmHg, and a central venous oxygen saturation of 70% within 6 h of diagnosis. In addition, early and appropriate introduction of ventilator assistance not only improves gas exchange, it further reduces the imbalance between oxygen delivery and utilisation. The mortality reduction is also accompanied by a decrease in duration of mechanical ventilation, vasopressor use, and intensive care unit and hospital length of stay.
UR - http://www.scopus.com/inward/record.url?scp=84905753794&partnerID=8YFLogxK
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U2 - 10.1183/1025448x.10004313
DO - 10.1183/1025448x.10004313
M3 - Article
AN - SCOPUS:84905753794
SN - 1025-448X
VL - 63
SP - 184
EP - 204
JO - European Respiratory Monograph
JF - European Respiratory Monograph
ER -