TY - JOUR
T1 - Eating at the Table of Another
T2 - Metabolomics of Host-Parasite Interactions
AU - Kafsack, Björn F.C.
AU - Llinás, Manuel
N1 - Funding Information:
We thank Bryson D. Bennett and Kellen L. Olszewski for valuable insight and comments on the manuscript. This work was funded by the Burroughs Wellcome Fund and an NIH Director's New Innovators award (1DP2OD001315-01) with support from the Center for Quantitative Biology (P50 GM071508). B.F.C.K. is a Howard Hughes Medical Institute Fellow of the Damon Runyon Cancer Research Foundation. We apologize to the numerous authors whose work we were unable to cite due to space limitations.
PY - 2010/2/18
Y1 - 2010/2/18
N2 - The application of metabolomics, the global analysis of metabolite levels, to the study of protozoan parasites has become an important tool for understanding the host-parasite relationship and holds promise for the development of direly needed therapeutics and improved diagnostics. Research advances over the past decade have opened the door for a systems biology approach to protozoan parasites with metabolomics, providing a crucial readout of metabolic activity. In this review, we highlight recent metabolomic approaches to protozoan parasites, including metabolite profiling, integration with genomics, transcription, and proteomic analysis, and the use of metabolic fingerprints for the diagnosis of parasitic infections.
AB - The application of metabolomics, the global analysis of metabolite levels, to the study of protozoan parasites has become an important tool for understanding the host-parasite relationship and holds promise for the development of direly needed therapeutics and improved diagnostics. Research advances over the past decade have opened the door for a systems biology approach to protozoan parasites with metabolomics, providing a crucial readout of metabolic activity. In this review, we highlight recent metabolomic approaches to protozoan parasites, including metabolite profiling, integration with genomics, transcription, and proteomic analysis, and the use of metabolic fingerprints for the diagnosis of parasitic infections.
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U2 - 10.1016/j.chom.2010.01.008
DO - 10.1016/j.chom.2010.01.008
M3 - Review article
C2 - 20159614
AN - SCOPUS:76249110141
SN - 1931-3128
VL - 7
SP - 90
EP - 99
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 2
ER -