TY - JOUR
T1 - Eating during the biological night is associated with nausea
AU - Zitting, Kirsi Marja
AU - Isherwood, Cheryl M.
AU - Yuan, Robin K.
AU - Wang, Wei
AU - Vujovic, Nina
AU - Münch, Miriam
AU - Cain, Sean W.
AU - Williams, Jonathan S.
AU - Buxton, Orfeu M.
AU - Czeisler, Charles A.
AU - Duffy, Jeanne F.
N1 - Funding Information:
These research studies were supported by the National Institutes of Health [grant numbers P01 AG009975 , R01 HL080978 , R01 HL094654 , and R01 HL148704 ], the Office of Naval Research [grant N00014-15-1-2408 ], and were carried out at the Brigham and Women’s Hospital Center for Clinical Investigation, supported by the Harvard Catalyst (Harvard Clinical and Translational Science Center supported by NIH Award UL1 TR001102 and financial contributions from the Brigham and Women’s Hospital and from Harvard University and its affiliated academic health care centers).
Publisher Copyright:
© 2023 National Sleep Foundation
PY - 2023
Y1 - 2023
N2 - Objectives: This study assessed whether there was a time-of-day effect on nausea reports in participants during studies employing circadian protocols. Methods: Visual-analog-scales of nausea ratings were recorded from 34 participants (18-70 years; 18 women) during forced desynchrony studies, where meals were scheduled at different circadian phases. Subjective nausea reports from a further 81 participants (18-35 years; 36 women) were recorded during constant routine studies, where they ate identical isocaloric hourly snacks for 36-40 hours. Results: Feelings of nausea varied by circadian phase in the forced desynchrony studies, peaking during the biological night. Nausea during the constant routine was reported by 27% of participants, commencing 2.9 ± 5.2 hours after the midpoint of usual sleep timing, but was never reported to start in the evening (4-9 PM). Conclusions: Nausea occurred more often during the biological night and early morning hours. This timing is relevant to overnight and early morning shift workers and suggests that a strategy to counteract that is to pay careful attention to meal timing.
AB - Objectives: This study assessed whether there was a time-of-day effect on nausea reports in participants during studies employing circadian protocols. Methods: Visual-analog-scales of nausea ratings were recorded from 34 participants (18-70 years; 18 women) during forced desynchrony studies, where meals were scheduled at different circadian phases. Subjective nausea reports from a further 81 participants (18-35 years; 36 women) were recorded during constant routine studies, where they ate identical isocaloric hourly snacks for 36-40 hours. Results: Feelings of nausea varied by circadian phase in the forced desynchrony studies, peaking during the biological night. Nausea during the constant routine was reported by 27% of participants, commencing 2.9 ± 5.2 hours after the midpoint of usual sleep timing, but was never reported to start in the evening (4-9 PM). Conclusions: Nausea occurred more often during the biological night and early morning hours. This timing is relevant to overnight and early morning shift workers and suggests that a strategy to counteract that is to pay careful attention to meal timing.
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U2 - 10.1016/j.sleh.2023.08.004
DO - 10.1016/j.sleh.2023.08.004
M3 - Article
C2 - 37730474
AN - SCOPUS:85171446366
SN - 2352-7218
VL - 10
SP - S144-S148
JO - Sleep health
JF - Sleep health
IS - 1
ER -