Efeito da pré-medicação com dose baixa de dexmedetomidina sobre o consumo de propofol em pacientes geriátricos com doença renal em estágio terminal

Translated title of the contribution: Effect of low dose dexmedetomidine premedication on propofol consumption in geriatric end stage renal disease patients

Pinar Ergenoglu, Sule Akin, Cagla Bali, Hatice Evren Eker, Oya Yalcin Cok, Anis Aribogan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background and objective: Sedation in dialysis dependent end-stage renal disease patients requires caution as a result of performing high doses of sedatives and its complications. Multidrug sedation regimens might be superior and advantage on lesser drug consumption and by the way adverse events which occur easily in end-stage renal disease patients. We evaluated the effects of dexmedetomidine premedication on propofol consumption, sedation levels with Observer's Assessment of Alertness and Sedation scores and the bispectral index and the hemodynamic changes, potential side effects in geriatric patients with end-stage renal disease who underwent hip fracture surgery under spinal anesthesia. Method: In this randomized, controlled, double-blind study 60 elderly patients (age ≥ 65 years) with end-stage renal disease and hip fracture scheduled for anterograde femoral intramedullary nailing were assigned to groups that received either intravenous saline infusion (Group C) or dexmedetomidine 0.5 μg/kg/10 min infusion for premedication (Group D). All the patients received propofol infusion after the induction of the spinal anesthesia. Results: Total propofol consumption, propofol dose required for targeted sedation levels according to Observer's Assessment of Alertness and Sedation scores and bispectral index levels, recovery times were significantly lower in Group D (p< 0.001). The time to reach to Observer's Assessment of Alertness and Sedation score 4 and to achieve bispectral index. ≤ 80 was significantly lower in Group C compared with Group D (p< 0.001). Adverse events were similar in both groups. Conclusion: Dexmedetomidine premedication lowers intraoperative propofol consumption to maintain targeted level of sedation. Therefore low dose dexmedetomidine premedication in addition to propofol infusion might be an alternative in geriatric patients with end-stage renal disease for sedation.

Translated title of the contributionEffect of low dose dexmedetomidine premedication on propofol consumption in geriatric end stage renal disease patients
Original languagePortuguese
Pages (from-to)326-332
Number of pages7
JournalBrazilian Journal of Anesthesiology (English Edition)
Volume65
Issue number5
DOIs
StatePublished - Sep 1 2015

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

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