Effect of 5-fluoro-2'-deoxyuridine on deoxyribonucleotide pools in vivo

E. J. Ritter; W. J. Scott; J. G. Wilson; B. C. Lampkin; John Neely

Effect of 5-fluoro-2'-deoxyuridine on deoxyribonucleotide pools in vivo

E. J. Ritter
, W. J. Scott
, J. G. Wilson
, B. C. Lampkin
, John Neely

Research output: Contribution to journal › Article › peer-review

Abstract

5-Fluoro-2'-deoxyuridine (FdUrd) lowered the dTTP levels in rapidly frozen 12-day W rat embryos and in a human neuroblastoma grown in nude N:NIH(S) mice to about 20% of control values. This effect was associated with greatly increased dCTP levels and reduction of dGTP levels essentially to zero. Elimination of the dGTP pool correlated tempoerally with the cytotoxicity of FdUrd. Extremely rapid fixation of tissue was required to avoid artifactually high deoxyribonucleoside triphosphate values.

Original language	English (US)
Pages (from-to)	603-605
Number of pages	3
Journal	Journal of the National Cancer Institute
Volume	65
Issue number	3
State	Published - Oct 10 1980

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Cite this

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title = "Effect of 5-fluoro-2'-deoxyuridine on deoxyribonucleotide pools in vivo",

abstract = "5-Fluoro-2'-deoxyuridine (FdUrd) lowered the dTTP levels in rapidly frozen 12-day W rat embryos and in a human neuroblastoma grown in nude N:NIH(S) mice to about 20\% of control values. This effect was associated with greatly increased dCTP levels and reduction of dGTP levels essentially to zero. Elimination of the dGTP pool correlated tempoerally with the cytotoxicity of FdUrd. Extremely rapid fixation of tissue was required to avoid artifactually high deoxyribonucleoside triphosphate values.",

author = "Ritter, \{E. J.\} and Scott, \{W. J.\} and Wilson, \{J. G.\} and Lampkin, \{B. C.\} and John Neely",

year = "1980",

month = oct,

day = "10",

language = "English (US)",

volume = "65",

pages = "603--605",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Effect of 5-fluoro-2'-deoxyuridine on deoxyribonucleotide pools in vivo

AU - Ritter, E. J.

AU - Scott, W. J.

AU - Wilson, J. G.

AU - Lampkin, B. C.

AU - Neely, John

PY - 1980/10/10

Y1 - 1980/10/10

N2 - 5-Fluoro-2'-deoxyuridine (FdUrd) lowered the dTTP levels in rapidly frozen 12-day W rat embryos and in a human neuroblastoma grown in nude N:NIH(S) mice to about 20% of control values. This effect was associated with greatly increased dCTP levels and reduction of dGTP levels essentially to zero. Elimination of the dGTP pool correlated tempoerally with the cytotoxicity of FdUrd. Extremely rapid fixation of tissue was required to avoid artifactually high deoxyribonucleoside triphosphate values.

AB - 5-Fluoro-2'-deoxyuridine (FdUrd) lowered the dTTP levels in rapidly frozen 12-day W rat embryos and in a human neuroblastoma grown in nude N:NIH(S) mice to about 20% of control values. This effect was associated with greatly increased dCTP levels and reduction of dGTP levels essentially to zero. Elimination of the dGTP pool correlated tempoerally with the cytotoxicity of FdUrd. Extremely rapid fixation of tissue was required to avoid artifactually high deoxyribonucleoside triphosphate values.

UR - https://www.scopus.com/pages/publications/0018974761

UR - https://www.scopus.com/pages/publications/0018974761#tab=citedBy

M3 - Article

C2 - 6447821

AN - SCOPUS:0018974761

SN - 0027-8874

VL - 65

SP - 603

EP - 605

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 3

ER -

Effect of 5-fluoro-2'-deoxyuridine on deoxyribonucleotide pools in vivo

Abstract

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