Effect of ambient gas and crystal features on Doppler ultrasound twinkling of pathological mineralizations

Eric Rokni, Julianna C. Simon

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Color Doppler twinkling on kidney stones and other pathological mineralizations is theorized to arise from stable microbubbles, which suggests twinkling will be sensitive to ambient gas. Here, lab-grown cholesterol, calcium phosphate, and uric acid crystals were imaged with ultrasound in water while varying oxygen, carbon dioxide, and nitrogen levels. Twinkling was found to increase on cholesterol in elevated oxygen, cholesterol and calcium phosphate in elevated carbon dioxide, and no crystals in elevated nitrogen. These results support the crevice microbubble theory of twinkling and suggest gases may be varied to enhance twinkling on some mineralizations.

Original languageEnglish (US)
Pages (from-to)3397-3402
Number of pages6
JournalJournal of the Acoustical Society of America
Issue number5
StatePublished - Nov 1 2023

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Acoustics and Ultrasonics

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