TY - JOUR
T1 - Effect of Anger Provocation on Endothelium-Dependent and -Independent Vasodilation
AU - Shimbo, Daichi
AU - Chaplin, William
AU - Akinola, Oluwaseun
AU - Harris, Adam
AU - Abraham, Dennis
AU - Homma, Shunichi
AU - Gerin, William
N1 - Funding Information:
This work was supported by Grants RR00645, HL072866, and HL076857 from the National Institutes of Health, Bethesda, Maryland.
PY - 2007/3/15
Y1 - 2007/3/15
N2 - Anger is an independent predictor of coronary heart disease events, although the mechanisms for this relation are unclear. The effects of an anger-provoking interview compared with a neutral interview on endothelium-dependent and -independent vasodilation assessed by brachial artery ultrasound were examined in 14 healthy subjects without coronary heart disease risk factors. The anger provocation condition, but not the neutral condition, caused a significant impairment in endothelium-dependent vasodilation at 90 minutes compared with baseline (p = 0.004) and 30 minutes (p = 0.013). Similarly, endothelium-independent vasodilation was significantly impaired at 90 minutes after the angry interview compared with baseline (p = 0.003) and 30 minutes (p = 0.001). The decreases in endothelium-dependent and -independent vasodilation were greater after the anger-provoking interview than after the neutral interview, especially between 30 and 90 minutes. In conclusion, preliminary results suggest that an episode of anger is associated with a dysregulation in endothelium-dependent and -independent pathways, suggesting that these mechanisms might contribute to the link between anger and coronary heart disease events.
AB - Anger is an independent predictor of coronary heart disease events, although the mechanisms for this relation are unclear. The effects of an anger-provoking interview compared with a neutral interview on endothelium-dependent and -independent vasodilation assessed by brachial artery ultrasound were examined in 14 healthy subjects without coronary heart disease risk factors. The anger provocation condition, but not the neutral condition, caused a significant impairment in endothelium-dependent vasodilation at 90 minutes compared with baseline (p = 0.004) and 30 minutes (p = 0.013). Similarly, endothelium-independent vasodilation was significantly impaired at 90 minutes after the angry interview compared with baseline (p = 0.003) and 30 minutes (p = 0.001). The decreases in endothelium-dependent and -independent vasodilation were greater after the anger-provoking interview than after the neutral interview, especially between 30 and 90 minutes. In conclusion, preliminary results suggest that an episode of anger is associated with a dysregulation in endothelium-dependent and -independent pathways, suggesting that these mechanisms might contribute to the link between anger and coronary heart disease events.
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U2 - 10.1016/j.amjcard.2006.10.051
DO - 10.1016/j.amjcard.2006.10.051
M3 - Article
C2 - 17350383
AN - SCOPUS:33847615750
SN - 0002-9149
VL - 99
SP - 860
EP - 863
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 6
ER -