TY - GEN
T1 - Effect of controlled rate freezing on the microstructural properties of poly (l-lactic acid) scaffolds
AU - Chinnasami, Harish
AU - Idicula, George
AU - Hayes, Daniel J.
AU - Devireddy, Ram
PY - 2012
Y1 - 2012
N2 - Bio-degradable poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermally induced phase separation (TIPS) method. A solution of PLLA-Dioxane was formed by dissolving PLLA in dehydrated 1,4-Dioxane at three wt/vol percentages, specifically 3, 7 and 10%. This PLLA-Dioxane solution was then frozen in borosilicate glass vials (5mL) at three cooling rates (1, 10 and 40 °C/min) in a commercially available controlled rate freezer (CRF). The frozen solution was freeze-dried to sublimate the dioxane. The microstructural properties of the resulting PLLA scaffolds were determined utilizing Scanning Electron Microscopy (SEM) images and uniaxial compressive testing. The relationship between the wt/vol ratio of PLLA and Dioxane and the imposed cooling rates on the structural properties of PLLA scaffolds was determined.
AB - Bio-degradable poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermally induced phase separation (TIPS) method. A solution of PLLA-Dioxane was formed by dissolving PLLA in dehydrated 1,4-Dioxane at three wt/vol percentages, specifically 3, 7 and 10%. This PLLA-Dioxane solution was then frozen in borosilicate glass vials (5mL) at three cooling rates (1, 10 and 40 °C/min) in a commercially available controlled rate freezer (CRF). The frozen solution was freeze-dried to sublimate the dioxane. The microstructural properties of the resulting PLLA scaffolds were determined utilizing Scanning Electron Microscopy (SEM) images and uniaxial compressive testing. The relationship between the wt/vol ratio of PLLA and Dioxane and the imposed cooling rates on the structural properties of PLLA scaffolds was determined.
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U2 - 10.1115/IMECE2012-87558
DO - 10.1115/IMECE2012-87558
M3 - Conference contribution
AN - SCOPUS:84887287308
SN - 9780791845189
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
SP - 651
EP - 656
BT - ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012
T2 - ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012
Y2 - 9 November 2012 through 15 November 2012
ER -