Effect of controlled rate freezing on the microstructural properties of poly (l-lactic acid) scaffolds

Harish Chinnasami; George Idicula; Daniel J. Hayes; Ram Devireddy

doi:10.1115/IMECE2012-87558

Effect of controlled rate freezing on the microstructural properties of poly (l-lactic acid) scaffolds

Harish Chinnasami, George Idicula, Daniel J. Hayes, Ram Devireddy

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Bio-degradable poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermally induced phase separation (TIPS) method. A solution of PLLA-Dioxane was formed by dissolving PLLA in dehydrated 1,4-Dioxane at three wt/vol percentages, specifically 3, 7 and 10%. This PLLA-Dioxane solution was then frozen in borosilicate glass vials (5mL) at three cooling rates (1, 10 and 40 °C/min) in a commercially available controlled rate freezer (CRF). The frozen solution was freeze-dried to sublimate the dioxane. The microstructural properties of the resulting PLLA scaffolds were determined utilizing Scanning Electron Microscopy (SEM) images and uniaxial compressive testing. The relationship between the wt/vol ratio of PLLA and Dioxane and the imposed cooling rates on the structural properties of PLLA scaffolds was determined.

Original language	English (US)
Title of host publication	ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012
Pages	651-656
Number of pages	6
Volume	2
DOIs	https://doi.org/10.1115/IMECE2012-87558
State	Published - Dec 1 2012
Event	ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012 - Houston, TX, United States Duration: Nov 9 2012 → Nov 15 2012

Other

Other	ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012
Country/Territory	United States
City	Houston, TX
Period	11/9/12 → 11/15/12

All Science Journal Classification (ASJC) codes

Mechanical Engineering

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10.1115/IMECE2012-87558

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@inproceedings{81fd5c0daee44d31adfe0402d805c672,

title = "Effect of controlled rate freezing on the microstructural properties of poly (l-lactic acid) scaffolds",

abstract = "Bio-degradable poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermally induced phase separation (TIPS) method. A solution of PLLA-Dioxane was formed by dissolving PLLA in dehydrated 1,4-Dioxane at three wt/vol percentages, specifically 3, 7 and 10%. This PLLA-Dioxane solution was then frozen in borosilicate glass vials (5mL) at three cooling rates (1, 10 and 40 °C/min) in a commercially available controlled rate freezer (CRF). The frozen solution was freeze-dried to sublimate the dioxane. The microstructural properties of the resulting PLLA scaffolds were determined utilizing Scanning Electron Microscopy (SEM) images and uniaxial compressive testing. The relationship between the wt/vol ratio of PLLA and Dioxane and the imposed cooling rates on the structural properties of PLLA scaffolds was determined.",

author = "Harish Chinnasami and George Idicula and Hayes, {Daniel J.} and Ram Devireddy",

year = "2012",

month = dec,

day = "1",

doi = "10.1115/IMECE2012-87558",

language = "English (US)",

isbn = "9780791845189",

volume = "2",

pages = "651--656",

booktitle = "ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012",

note = "ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012 ; Conference date: 09-11-2012 Through 15-11-2012",

}

Chinnasami, H, Idicula, G, Hayes, DJ & Devireddy, R 2012, Effect of controlled rate freezing on the microstructural properties of poly (l-lactic acid) scaffolds. in ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012. vol. 2, pp. 651-656, ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012, Houston, TX, United States, 11/9/12. https://doi.org/10.1115/IMECE2012-87558

TY - GEN

T1 - Effect of controlled rate freezing on the microstructural properties of poly (l-lactic acid) scaffolds

AU - Chinnasami, Harish

AU - Idicula, George

AU - Hayes, Daniel J.

AU - Devireddy, Ram

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Bio-degradable poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermally induced phase separation (TIPS) method. A solution of PLLA-Dioxane was formed by dissolving PLLA in dehydrated 1,4-Dioxane at three wt/vol percentages, specifically 3, 7 and 10%. This PLLA-Dioxane solution was then frozen in borosilicate glass vials (5mL) at three cooling rates (1, 10 and 40 °C/min) in a commercially available controlled rate freezer (CRF). The frozen solution was freeze-dried to sublimate the dioxane. The microstructural properties of the resulting PLLA scaffolds were determined utilizing Scanning Electron Microscopy (SEM) images and uniaxial compressive testing. The relationship between the wt/vol ratio of PLLA and Dioxane and the imposed cooling rates on the structural properties of PLLA scaffolds was determined.

AB - Bio-degradable poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermally induced phase separation (TIPS) method. A solution of PLLA-Dioxane was formed by dissolving PLLA in dehydrated 1,4-Dioxane at three wt/vol percentages, specifically 3, 7 and 10%. This PLLA-Dioxane solution was then frozen in borosilicate glass vials (5mL) at three cooling rates (1, 10 and 40 °C/min) in a commercially available controlled rate freezer (CRF). The frozen solution was freeze-dried to sublimate the dioxane. The microstructural properties of the resulting PLLA scaffolds were determined utilizing Scanning Electron Microscopy (SEM) images and uniaxial compressive testing. The relationship between the wt/vol ratio of PLLA and Dioxane and the imposed cooling rates on the structural properties of PLLA scaffolds was determined.

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DO - 10.1115/IMECE2012-87558

M3 - Conference contribution

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VL - 2

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EP - 656

BT - ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012

T2 - ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012

Y2 - 9 November 2012 through 15 November 2012

ER -

Effect of controlled rate freezing on the microstructural properties of poly (l-lactic acid) scaffolds

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