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Effect of COX-2-Specific Inhibition on Fracture-Healing in the Rat Femur
Karen M. Brown
, Marnie M. Saunders
, Thorsten Kirsch
, Henry J. Donahue
, J. Spence Reid
Department of Orthopaedics and Therapy Services
Division of Trauma
Research output
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Contribution to journal
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Article
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peer-review
150
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Keyphrases
Fracture Healing
100%
Cyclooxygenase-2
100%
Specific Inhibition
100%
Celecoxib
100%
Healing
80%
COX-2 Inhibitors
60%
Callus
40%
Mechanical Strength
40%
Non-steroidal Anti-inflammatory Drugs (NSAIDs)
40%
Indomethacin
40%
Bone Formation
40%
Fibrous Tissue
40%
Femur
40%
Radiological Signs
40%
Callus Formation
40%
Morphological Changes
20%
Stiffness
20%
No Significant Difference
20%
Analgesia
20%
Clinical Significance
20%
Narcotics
20%
Postoperative Pain
20%
Adult Rats
20%
Three-point Bending Test
20%
Adult Male Rats
20%
Cartilage
20%
Delayed Healing
20%
Bone Healing
20%
Postoperative Day
20%
Bone Remodeling
20%
Human Use
20%
Fracture Union
20%
Mechanical Stiffness
20%
Woven Bone
20%
Post-fracture
20%
Medicine and Dentistry
Fracture Healing
100%
Celecoxib
100%
Callus
80%
Cyclooxygenase 2 Inhibitor
60%
Morphology
40%
Anti-Inflammatory Drug
40%
Ossification
40%
Indometacin
40%
Side Effect
20%
Analgesia
20%
Postoperative Pain
20%
Osteoplasty
20%
Nonunion
20%
Cartilage
20%
Bone Remodeling
20%
Pharmacology, Toxicology and Pharmaceutical Science
Fracture Healing
100%
Celecoxib
100%
Callus
80%
COX-2 Inhibitor
60%
Anti-Inflammatory Drug
40%
Indometacin
40%
Side Effect
20%
Narcotic Agent
20%
Postoperative Pain
20%
Fracture Nonunion
20%