TY - JOUR
T1 - Effect of Cyclooxygenase Inhibition on Peripheral Venous Distension Reflex in Healthy Humans
AU - Hamaoka, Takuto
AU - Leuenberger, Urs A.
AU - Kronfli, Anthony
AU - Gao, Zhaohui
AU - Blaha, Cheryl
AU - Carter Luck, Jonathan
AU - Dalton, Paul
AU - Sinoway, Lawrence I.
AU - Cui, Jian
N1 - Publisher Copyright:
© 2023 American Heart Association, Inc.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Background: Peripheral venous distension evokes a pressor reflex (venous distension reflex). Afferent group III and IV nerves innervating veins are suggested as the afferent arm of the venous distension reflex. Prostaglandins stimulate/sensitize group III/IV nerves. We hypothesized that inhibition of prostaglandin synthesis by local cyclooxygenase blockade would attenuate the muscle sympathetic nerve activity (MSNA) and blood pressure responses to venous distension. Methods: Nineteen healthy volunteers (age, 27±5 years) participated in the study with 2 visits. To induce venous distension, a volume of solution (saline alone or 9 mg ketorolac tromethamine in saline) was infused into the vein in the antecubital fossa of an arterially occluded forearm. During the procedure, beat-by-beat heart rate, blood pressure and MSNA were recorded simultaneously. The vein size was measured with ultrasound. Results: In both visits, the venous distension procedure significantly increased blood pressure, heart rate, and MSNA (all, P<0.05). The increase in mean arterial pressure and MSNA in the ketorolac visit was significantly lower than in the control visit (Δ mean arterial pressure, 7.0±6.2 versus 13.8±7.7 mm Hg; ΔMSNA, 6.0±7.1 versus 14.8±7.7 bursts/min; both, P<0.05). The increase in vein size induced by the infusion was not different between visits. Conclusions: The presented data show that cyclooxygenase blockade attenuates the responses in MSNA and blood pressure to peripheral venous distension reflex. The results suggest that cyclooxygenase products play a key role in evoking afferent activation responsible for the venous distension reflex.
AB - Background: Peripheral venous distension evokes a pressor reflex (venous distension reflex). Afferent group III and IV nerves innervating veins are suggested as the afferent arm of the venous distension reflex. Prostaglandins stimulate/sensitize group III/IV nerves. We hypothesized that inhibition of prostaglandin synthesis by local cyclooxygenase blockade would attenuate the muscle sympathetic nerve activity (MSNA) and blood pressure responses to venous distension. Methods: Nineteen healthy volunteers (age, 27±5 years) participated in the study with 2 visits. To induce venous distension, a volume of solution (saline alone or 9 mg ketorolac tromethamine in saline) was infused into the vein in the antecubital fossa of an arterially occluded forearm. During the procedure, beat-by-beat heart rate, blood pressure and MSNA were recorded simultaneously. The vein size was measured with ultrasound. Results: In both visits, the venous distension procedure significantly increased blood pressure, heart rate, and MSNA (all, P<0.05). The increase in mean arterial pressure and MSNA in the ketorolac visit was significantly lower than in the control visit (Δ mean arterial pressure, 7.0±6.2 versus 13.8±7.7 mm Hg; ΔMSNA, 6.0±7.1 versus 14.8±7.7 bursts/min; both, P<0.05). The increase in vein size induced by the infusion was not different between visits. Conclusions: The presented data show that cyclooxygenase blockade attenuates the responses in MSNA and blood pressure to peripheral venous distension reflex. The results suggest that cyclooxygenase products play a key role in evoking afferent activation responsible for the venous distension reflex.
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U2 - 10.1161/HYPERTENSIONAHA.122.20506
DO - 10.1161/HYPERTENSIONAHA.122.20506
M3 - Article
C2 - 36942572
AN - SCOPUS:85153724769
SN - 0194-911X
VL - 80
SP - 1102
EP - 1109
JO - Hypertension
JF - Hypertension
IS - 5
ER -