TY - JOUR
T1 - Effect of exposure to second-hand smoke from husbands on biochemical hyperandrogenism, metabolic syndrome and conception rates in women with polycystic ovary syndrome undergoing ovulation induction
AU - Li, Jian
AU - Wu, Q.
AU - Wu, Xiao Ke
AU - Zhou, Zhong Ming
AU - Fu, Ping
AU - Chen, Xiu Hua
AU - Yan, Ying
AU - Wang, Xin
AU - Yang, Zheng Wang
AU - Li, Wei Li
AU - Stener-Victorin, Elisabet
AU - Legro, Richard S.
AU - Ng, Ernest Hung Yu
AU - Zhang, Heping
AU - Mol, Ben Willem J.
AU - Wang, Chi Chiu
N1 - Funding Information:
National Public Welfare Projects for Chinese Medicine (201107005, 200807002), the National Key Discipline of Chinese Medicine in Gynecology during the year of 2009–2016, the Heilongjiang Province Foundation for Outstanding Youths (JC200804), the Intervention for Polycystic Ovary Syndrome Based on Traditional Chinese Medicine Theory—‘Tian Gui Disorder’ (2011TD006), and the National Clinical Trial Base in Chinese Medicine Special Projects (JDZX2012036, 2015B009) during the year of 2009–2016 for the First Affiliated Hospital, Heilongjiang University of Chinese Medicine, as well as the Heilongjiang Province ‘Longjiang Scholar’ Program to X.-K.W.
Funding Information:
The content is solely the responsibility of the authors and does not necessarily represent the official views of the State Administration of Traditional Chinese Medicine of People’s Republic of China. The Steering Committee (SC) members included Xiao-Ke Wu, Jiang-Ping Liu, Tai-Xiang Wu, Ernest HY Ng, Elisabet Stener-Victorin and Heping Zhang, and Richard S Legro (Chair). The Data and Safety Monitoring Board (DSMB) members included Esther Eisenberg, Wei-Liang Weng, Su-Lun Sun, Wei Zou and Zi-Dan Chen, and Robert Rebar (Chair). Meizhuo Zhang in Yale, contributed to the randomization scheme and training of our study personnel. Jin-Ying Fu, Chang-Ling Zhu and Xiao-Hong Wang participated in the patient recruitment at local sites of Henan, Wenzhou and Xuzhou. Other personnel with administrative resource supports included Song-Jiang Liu, Gui-Yuan Wang, Yan-Qiu Du, Yang Xia, Shu-Lai Li, Ke-Qiu Zhang and Jian-Hua Shen. Yan Li, Wen-Juan Shen, Wei Li and Jing Cong were involved in protocol preparation and blood sample management in the Harbin office and core laboratory. We thank the Reproductive Medicine Network Steering Committee of the National Institutes of Health for sharing the protocol and case-report forms from the Pregnancy in Polycystic Ovary Syndrome II study.
Publisher Copyright:
© The Author(s) 2018.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - STUDY DESIGN, SIZE, DURATION: This study was a secondary analysis of the Polycystic Ovary Syndrome Acupuncture and Clomiphene Trial (PCOSAct), a large randomized controlled trial conducted at 27 hospitals from 2012 to 2015 in mainland China. PARTICIPANTS/MATERIALS, SETTING, METHODS: Out of 1000 women with PCOS, SHS exposure status were available in 500 women, of whom 271 women were non-exposed and 229 exposed to cigarette smoke (170 women ?10 cigarettes per day as low-SHS exposed and 59 women >10 cigarettes per day as high-SHS exposed). We compared circulating sex steroids, glucose and lipid metabolism, metabolic syndrome and phenotypes, fertility and obstetric outcomes between non-exposed and exposed women. MAIN RESULTS AND THE ROLE OF CHANCE: Women exposed to SHS, compared to non-exposed women, had a higher serum total testosterone (1.7 vs 1.5 nmol/L, P = 0.01), free androgen index (5.7 vs 4.0, P = 0.001) and lower sex hormone binding globulin (30.1 vs 35.6 nmol/L, P = 0.03). Metabolic syndrome, but not other phenotypes, was more frequent in exposed women as compared to nonexposed women (21.8 vs 13.3%, adjusted odds ratio (OR)=1.66; 95% CI, 1.022.71, P = 0.04). Ovulation rates between exposed and nonexposed groups were not significantly different (76.9 vs 82.9%, adjusted OR=0.72; 95% CI, 0.451.15, P = 0.17). Conception rates were significant lower in the exposed group (26.6 vs 36.9%; adjusted OR=0.61; 95% CI, 0.410.91; P = 0.01), while clinical pregnancy and live birth rates showed a similar trend that was not statistically significant. Gestational age, birth weight and other obstetric outcomes were not affected by SHS exposure. LIMITATIONS, REASONS FOR CAUTION: Data on SHS exposure were missing in 50% of the women. We did not assay serum nicotine or cotinine levels to quantify the SHS exposure status. WIDER IMPLICATIONS OF THE FINDINGS: These data suggest that smoking partners of infertile women with PCOS who seek treatment should be advised to quit smoking.
AB - STUDY DESIGN, SIZE, DURATION: This study was a secondary analysis of the Polycystic Ovary Syndrome Acupuncture and Clomiphene Trial (PCOSAct), a large randomized controlled trial conducted at 27 hospitals from 2012 to 2015 in mainland China. PARTICIPANTS/MATERIALS, SETTING, METHODS: Out of 1000 women with PCOS, SHS exposure status were available in 500 women, of whom 271 women were non-exposed and 229 exposed to cigarette smoke (170 women ?10 cigarettes per day as low-SHS exposed and 59 women >10 cigarettes per day as high-SHS exposed). We compared circulating sex steroids, glucose and lipid metabolism, metabolic syndrome and phenotypes, fertility and obstetric outcomes between non-exposed and exposed women. MAIN RESULTS AND THE ROLE OF CHANCE: Women exposed to SHS, compared to non-exposed women, had a higher serum total testosterone (1.7 vs 1.5 nmol/L, P = 0.01), free androgen index (5.7 vs 4.0, P = 0.001) and lower sex hormone binding globulin (30.1 vs 35.6 nmol/L, P = 0.03). Metabolic syndrome, but not other phenotypes, was more frequent in exposed women as compared to nonexposed women (21.8 vs 13.3%, adjusted odds ratio (OR)=1.66; 95% CI, 1.022.71, P = 0.04). Ovulation rates between exposed and nonexposed groups were not significantly different (76.9 vs 82.9%, adjusted OR=0.72; 95% CI, 0.451.15, P = 0.17). Conception rates were significant lower in the exposed group (26.6 vs 36.9%; adjusted OR=0.61; 95% CI, 0.410.91; P = 0.01), while clinical pregnancy and live birth rates showed a similar trend that was not statistically significant. Gestational age, birth weight and other obstetric outcomes were not affected by SHS exposure. LIMITATIONS, REASONS FOR CAUTION: Data on SHS exposure were missing in 50% of the women. We did not assay serum nicotine or cotinine levels to quantify the SHS exposure status. WIDER IMPLICATIONS OF THE FINDINGS: These data suggest that smoking partners of infertile women with PCOS who seek treatment should be advised to quit smoking.
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U2 - 10.1093/humrep/dey027
DO - 10.1093/humrep/dey027
M3 - Article
C2 - 29471520
AN - SCOPUS:85044715706
SN - 0268-1161
VL - 33
SP - 617
EP - 625
JO - Human Reproduction
JF - Human Reproduction
IS - 4
ER -