TY - JOUR
T1 - Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity
T2 - A Randomized Trial
AU - Lichtenstein, Alice H.
AU - Kris-Etherton, Penny M.
AU - Petersen, Kristina S.
AU - Matthan, Nirupa R.
AU - Barnes, Samuel
AU - Vitolins, Mara Z.
AU - Li, Zhaoping
AU - Sabaté, Joan
AU - Rajaram, Sujatha
AU - Chowdhury, Shilpy
AU - Davis, Kristin M.
AU - Galluccio, Jean
AU - Gilhooly, Cheryl H.
AU - Legro, Richard S.
AU - Li, Jason
AU - Lovato, Laura
AU - Perdue, Letitia H.
AU - Petty, Gayle
AU - Rasmussen, Anna M.
AU - Segovia-Siapco, Gina
AU - Sirirat, Rawiwan
AU - Sun, April
AU - Reboussin, David M.
N1 - Publisher Copyright:
© 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
PY - 2022/7/19
Y1 - 2022/7/19
N2 - BACKGROUND: Excess visceral adiposity is associated with increased risk of cardiometabolic disorders. Short-term well-controlled clinical trials suggest that regular avocado consumption favorably affects body weight, visceral adiposity, and satiety. METHODS AND RESULTS: The HAT Trial (Habitual Diet and Avocado Trial) was a multicenter, randomized, controlled parallel-arm trial designed to test whether consuming 1 large avocado per day for 6months in a diverse group of free-living individuals (N=1008) with an elevated waist circumference compared with a habitual diet would decrease visceral adiposity as measured by magnetic resonance imaging. Secondary and additional end points related to risk factors associated with cardiometabolic disorders were assessed. The primary outcome, change in visceral adipose tissue volume during the intervention period, was not significantly different between the Avocado Supplemented and Habitual Diet Groups (estimated mean difference (0.017L [−0.024L, 0.058L], P=0.405). No significant group differences were observed for the secondary outcomes of hepatic fat fraction, hsCRP (high-sensitivity C-reactive protein), and components of the metabolic syndrome. Of the additional outcome measures, modest but nominally significant reductions in total and low-density lipoprotein cholesterol were observed in the Avocado Supplemented compared with the Habitual Diet Group. Changes in the other additional and post hoc measures (body weight, body mass index, insulin, very low-density lipoprotein concentrations, and total cholesterol:high-density lipoprotein cholesterol ratio) were similar between the 2 groups. CONCLUSIONS: Addition of 1 avocado per day to the habitual diet for 6 months in free-living individuals with elevated waist circumference did not reduce visceral adipose tissue volume and had minimal effect on risk factors associated with cardio-metabolic disorders.
AB - BACKGROUND: Excess visceral adiposity is associated with increased risk of cardiometabolic disorders. Short-term well-controlled clinical trials suggest that regular avocado consumption favorably affects body weight, visceral adiposity, and satiety. METHODS AND RESULTS: The HAT Trial (Habitual Diet and Avocado Trial) was a multicenter, randomized, controlled parallel-arm trial designed to test whether consuming 1 large avocado per day for 6months in a diverse group of free-living individuals (N=1008) with an elevated waist circumference compared with a habitual diet would decrease visceral adiposity as measured by magnetic resonance imaging. Secondary and additional end points related to risk factors associated with cardiometabolic disorders were assessed. The primary outcome, change in visceral adipose tissue volume during the intervention period, was not significantly different between the Avocado Supplemented and Habitual Diet Groups (estimated mean difference (0.017L [−0.024L, 0.058L], P=0.405). No significant group differences were observed for the secondary outcomes of hepatic fat fraction, hsCRP (high-sensitivity C-reactive protein), and components of the metabolic syndrome. Of the additional outcome measures, modest but nominally significant reductions in total and low-density lipoprotein cholesterol were observed in the Avocado Supplemented compared with the Habitual Diet Group. Changes in the other additional and post hoc measures (body weight, body mass index, insulin, very low-density lipoprotein concentrations, and total cholesterol:high-density lipoprotein cholesterol ratio) were similar between the 2 groups. CONCLUSIONS: Addition of 1 avocado per day to the habitual diet for 6 months in free-living individuals with elevated waist circumference did not reduce visceral adipose tissue volume and had minimal effect on risk factors associated with cardio-metabolic disorders.
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U2 - 10.1161/JAHA.122.025657
DO - 10.1161/JAHA.122.025657
M3 - Article
C2 - 35861827
AN - SCOPUS:85134601166
SN - 2047-9980
VL - 11
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 14
M1 - e025657
ER -