Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial

Alice H. Lichtenstein, Penny M. Kris-Etherton, Kristina S. Petersen, Nirupa R. Matthan, Samuel Barnes, Mara Z. Vitolins, Zhaoping Li, Joan Sabaté, Sujatha Rajaram, Shilpy Chowdhury, Kristin M. Davis, Jean Galluccio, Cheryl H. Gilhooly, Richard S. Legro, Jason Li, Laura Lovato, Letitia H. Perdue, Gayle Petty, Anna M. Rasmussen, Gina Segovia-SiapcoRawiwan Sirirat, April Sun, David M. Reboussin

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


BACKGROUND: Excess visceral adiposity is associated with increased risk of cardiometabolic disorders. Short-term well-controlled clinical trials suggest that regular avocado consumption favorably affects body weight, visceral adiposity, and satiety. METHODS AND RESULTS: The HAT Trial (Habitual Diet and Avocado Trial) was a multicenter, randomized, controlled parallel-arm trial designed to test whether consuming 1 large avocado per day for 6months in a diverse group of free-living individuals (N=1008) with an elevated waist circumference compared with a habitual diet would decrease visceral adiposity as measured by magnetic resonance imaging. Secondary and additional end points related to risk factors associated with cardiometabolic disorders were assessed. The primary outcome, change in visceral adipose tissue volume during the intervention period, was not significantly different between the Avocado Supplemented and Habitual Diet Groups (estimated mean difference (0.017L [−0.024L, 0.058L], P=0.405). No significant group differences were observed for the secondary outcomes of hepatic fat fraction, hsCRP (high-sensitivity C-reactive protein), and components of the metabolic syndrome. Of the additional outcome measures, modest but nominally significant reductions in total and low-density lipoprotein cholesterol were observed in the Avocado Supplemented compared with the Habitual Diet Group. Changes in the other additional and post hoc measures (body weight, body mass index, insulin, very low-density lipoprotein concentrations, and total cholesterol:high-density lipoprotein cholesterol ratio) were similar between the 2 groups. CONCLUSIONS: Addition of 1 avocado per day to the habitual diet for 6 months in free-living individuals with elevated waist circumference did not reduce visceral adipose tissue volume and had minimal effect on risk factors associated with cardio-metabolic disorders.

Original languageEnglish (US)
Article numbere025657
JournalJournal of the American Heart Association
Issue number14
StatePublished - Jul 19 2022

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial'. Together they form a unique fingerprint.

Cite this