Effect of intramuscular triamcinolone acetonide on the human ovulatory cycle

T. E. Carson; T. A. Daane; P. A. Lee; D. R. Tredway; J. D. Wallin

Effect of intramuscular triamcinolone acetonide on the human ovulatory cycle

T. E. Carson, T. A. Daane, P. A. Lee, D. R. Tredway, J. D. Wallin

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Abstract

The effect of triamcinolone acetonide (TCA-A) im on pituitary gonadotropins and ovarian hormones was studied in a normally menstruating woman. Serum levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), as well as estradiol-17beta (E2) and progesterone (P), were determined daily in a normal "ovulatory" pretreatment cycle. A total of 160 mg of TCA-A was then administered in 4 injections over 2 months. Daily serum levels of LH, FSH, E2, and P were again measured during a period beginning 30 days after the last injection of TCA-A. Cyclicity of all these hormones was absent after treatment. Both LH and FSH were suppressed in the 1st half of the posttreatment period when compared with the pretreatment ovulatory cycle. A potent corticosteroid such as TCA-A is apparently capable of producing anovulatory cycles in humans by disruption of cyclic pituitary gonadotropin secretion.

Original language	English (US)
Pages (from-to)	633-636
Number of pages	4
Journal	Cutis
Volume	19
Issue number	5
State	Published - 1977

All Science Journal Classification (ASJC) codes

Dermatology

Cite this

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abstract = "The effect of triamcinolone acetonide (TCA-A) im on pituitary gonadotropins and ovarian hormones was studied in a normally menstruating woman. Serum levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), as well as estradiol-17beta (E2) and progesterone (P), were determined daily in a normal {"}ovulatory{"} pretreatment cycle. A total of 160 mg of TCA-A was then administered in 4 injections over 2 months. Daily serum levels of LH, FSH, E2, and P were again measured during a period beginning 30 days after the last injection of TCA-A. Cyclicity of all these hormones was absent after treatment. Both LH and FSH were suppressed in the 1st half of the posttreatment period when compared with the pretreatment ovulatory cycle. A potent corticosteroid such as TCA-A is apparently capable of producing anovulatory cycles in humans by disruption of cyclic pituitary gonadotropin secretion.",

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T1 - Effect of intramuscular triamcinolone acetonide on the human ovulatory cycle

AU - Carson, T. E.

AU - Daane, T. A.

AU - Lee, P. A.

AU - Tredway, D. R.

AU - Wallin, J. D.

PY - 1977

Y1 - 1977

N2 - The effect of triamcinolone acetonide (TCA-A) im on pituitary gonadotropins and ovarian hormones was studied in a normally menstruating woman. Serum levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), as well as estradiol-17beta (E2) and progesterone (P), were determined daily in a normal "ovulatory" pretreatment cycle. A total of 160 mg of TCA-A was then administered in 4 injections over 2 months. Daily serum levels of LH, FSH, E2, and P were again measured during a period beginning 30 days after the last injection of TCA-A. Cyclicity of all these hormones was absent after treatment. Both LH and FSH were suppressed in the 1st half of the posttreatment period when compared with the pretreatment ovulatory cycle. A potent corticosteroid such as TCA-A is apparently capable of producing anovulatory cycles in humans by disruption of cyclic pituitary gonadotropin secretion.

AB - The effect of triamcinolone acetonide (TCA-A) im on pituitary gonadotropins and ovarian hormones was studied in a normally menstruating woman. Serum levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), as well as estradiol-17beta (E2) and progesterone (P), were determined daily in a normal "ovulatory" pretreatment cycle. A total of 160 mg of TCA-A was then administered in 4 injections over 2 months. Daily serum levels of LH, FSH, E2, and P were again measured during a period beginning 30 days after the last injection of TCA-A. Cyclicity of all these hormones was absent after treatment. Both LH and FSH were suppressed in the 1st half of the posttreatment period when compared with the pretreatment ovulatory cycle. A potent corticosteroid such as TCA-A is apparently capable of producing anovulatory cycles in humans by disruption of cyclic pituitary gonadotropin secretion.

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Effect of intramuscular triamcinolone acetonide on the human ovulatory cycle

Abstract

All Science Journal Classification (ASJC) codes

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