TY - JOUR
T1 - Effect of intravenous preoperative versus postoperative paracetamol on postoperative nausea and vomiting in patients undergoing strabismus surgery
T2 - A prospective randomized study
AU - Aksoy, Mehmet
AU - Ince, Ilker
AU - Ahiskaliolu, Ali
AU - Kele, Sadullah
AU - Doymu, Ömer
N1 - Publisher Copyright:
© 2018 Turkish Society of Algology.
PY - 2018/1
Y1 - 2018/1
N2 - Objectives: This prospective randomized study aimed to compare the efficacy of preoperative versus postoperative paracetamol on postoperative nausea and vomiting (PONV) in children undergoing strabismus surgery. Methods: Ninety-six patients were randomly divided into three equal groups (n=32). In the preoperative paracetamol group, patients received intravenous (IV) infusion of paracetamol [15 mg kg?1 (1.5 ml kg?1)] 1 h before surgery over 20 min and that of saline (1.5 ml kg?1) in the recovery room. In the postoperative paracetamol group, patients received IV infusion of saline (1.5 ml kg?1) 1 h before surgery over 20 min and that of paracetamol [15 mg kg?1 (1.5 ml kg?1)] in therecovery room. In the control group, patients received the IV infusion of saline (1.5 ml kg?1) pre- and postoperatively. Postoperative pain condition was evaluated using the Faces Pain Scale. In the recovery room, an observer recorded the pain score, complaints of nausea and vomiting, the need for rescue analgesics, and the need for antiemetic drug during 24 h postoperatively. Results: The incidence of nausea and vomiting during the first 0-6 h postoperatively was significantly lower in the preoperative paracetamol group than in the control and postoperative paracetamol groups (p<0.001). The number of patients requiring antiemetic administration during the first 0-6 and 6-12 h postoperatively was found to be higher in the control group than in the other groups (p<0.001, for all). Conclusion:The preoperative administration of paracetamol reduces PONV incidence in children undergoing strabismus surgery.
AB - Objectives: This prospective randomized study aimed to compare the efficacy of preoperative versus postoperative paracetamol on postoperative nausea and vomiting (PONV) in children undergoing strabismus surgery. Methods: Ninety-six patients were randomly divided into three equal groups (n=32). In the preoperative paracetamol group, patients received intravenous (IV) infusion of paracetamol [15 mg kg?1 (1.5 ml kg?1)] 1 h before surgery over 20 min and that of saline (1.5 ml kg?1) in the recovery room. In the postoperative paracetamol group, patients received IV infusion of saline (1.5 ml kg?1) 1 h before surgery over 20 min and that of paracetamol [15 mg kg?1 (1.5 ml kg?1)] in therecovery room. In the control group, patients received the IV infusion of saline (1.5 ml kg?1) pre- and postoperatively. Postoperative pain condition was evaluated using the Faces Pain Scale. In the recovery room, an observer recorded the pain score, complaints of nausea and vomiting, the need for rescue analgesics, and the need for antiemetic drug during 24 h postoperatively. Results: The incidence of nausea and vomiting during the first 0-6 h postoperatively was significantly lower in the preoperative paracetamol group than in the control and postoperative paracetamol groups (p<0.001). The number of patients requiring antiemetic administration during the first 0-6 and 6-12 h postoperatively was found to be higher in the control group than in the other groups (p<0.001, for all). Conclusion:The preoperative administration of paracetamol reduces PONV incidence in children undergoing strabismus surgery.
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U2 - 10.5505/agri.2017.65872
DO - 10.5505/agri.2017.65872
M3 - Article
C2 - 29450877
AN - SCOPUS:85045005441
SN - 1300-0012
VL - 30
SP - 1
EP - 7
JO - Agri Dergisi
JF - Agri Dergisi
IS - 1
ER -