@article{5765524b0ea24b4885961280f68d2d27,
title = "Effect of maternally administered heroin on the motor activity of rat offspring",
abstract = "The behavior of 21-day old rats whose mothers were administered heroin (5 mg/kg daily) throughout gestation and lactation was studied utilizing an activity wheel, activity cage, open field test, and step-down latency times from an elevated platform. The total score of all behavioral tasks of offspring from heroin-injected females was statistically different from that of pups from saline-injected mothers, with heroin-treated animals appearing more active.",
author = "Lasky, {D. I.} and Zagon, {I. S.} and McLaughlin, {P. J.}",
note = "Funding Information: Female (180-200g) and male (250-300g) Sprague-Dawley rats (Charles River Labs) were housed under controlled conditions \[14\] with water and Wayne Laboratory Chow available ad lib. All animals were allowed 6 days to acclimate to their surroundings before the beginning of drug injections. Females were treated with an intraperitoneal injection either once daily (0800) with 5 mg/kg or twice daily (1800 and 1800) with 2.5 mg/kg/injection of diacetylmorphine (heroin); control animals were treated with an equivalent volume of saline under similar conditions. Animals were weighed every 2 days and appropriate dosage adjustments made. Five days after the beginning of drug treatment, females This research was supported in part by American Cancer Society Grant No. PDT-27B and NIDA Grant DA 01618-01. We are grateful to Drs. C. Max Lang and Carl Thompson for providing equipment and facilities, and to the National Institute of Drug Abuse, Rockville, MD for the supply of heroin. 2Send reprint requests to: Dr. I. S. Zagon, Department of Anatomy, The Milton S. Hershey Medical Center, Hershey, PA 17033. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",
year = "1977",
month = sep,
doi = "10.1016/0091-3057(77)90147-2",
language = "English (US)",
volume = "7",
pages = "281--284",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "3",
}