TY - GEN
T1 - Effect of medical device substrate material on nanoparticulate silver efficacy
AU - Dair, Benita J.
AU - Saylor, David M.
AU - Kennedy, Kristen M.
AU - Casas, Rachel
PY - 2008
Y1 - 2008
N2 - Silver is one of the oldest known natural antimicrobial materials, the active form being the Ag+ ion, which disrupts critical cell functions in bacteria. Reducing the size of silver particles to the nanoscale regime increases the surface area and hence the availability of silver ions, thereby enhancing their potential antimicrobial efficacy relative to their bulk counterparts. Nanoparticulate silver systems have been used as antimicrobial agents for medical device applications such as bandages, wound dressings, surgical masks, endotracheal tubes, and catheters. However the surface onto which the silver nanoparticles are deposited will impact the availability of Ag+ ions due to the chemistry of the substrate surface and its affinity for silver ions. The effect of substrate material on the efficacy of nanoparticulate silver will be discussed, along with the implications of materials selection in medical device applications.
AB - Silver is one of the oldest known natural antimicrobial materials, the active form being the Ag+ ion, which disrupts critical cell functions in bacteria. Reducing the size of silver particles to the nanoscale regime increases the surface area and hence the availability of silver ions, thereby enhancing their potential antimicrobial efficacy relative to their bulk counterparts. Nanoparticulate silver systems have been used as antimicrobial agents for medical device applications such as bandages, wound dressings, surgical masks, endotracheal tubes, and catheters. However the surface onto which the silver nanoparticles are deposited will impact the availability of Ag+ ions due to the chemistry of the substrate surface and its affinity for silver ions. The effect of substrate material on the efficacy of nanoparticulate silver will be discussed, along with the implications of materials selection in medical device applications.
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M3 - Conference contribution
AN - SCOPUS:52649095440
SN - 9781420085075
SN - 9781420085044
T3 - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
SP - 188
EP - 189
BT - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
T2 - 2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
Y2 - 1 June 2008 through 5 June 2008
ER -