Effect of probenecid on the kinetics of epsilon‐aminocaproic acid

Barry H. Dvorchik; Kerry L. Katlic; Arthur H. Hayes; M. Elaine Eyster

doi:10.1038/clpt.1980.154

Effect of probenecid on the kinetics of epsilon‐aminocaproic acid

Barry H. Dvorchik, Kerry L. Katlic, Arthur H. Hayes, M. Elaine Eyster

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Abstract

Healthy male subjects received, 1 wk apart, single oral doses of epsilon‐aminocaproic acid (EACA) 100 mg/kg alone, EACA with probenecid (0.5 gm), or EACA 2 hr after 2.0 gm probenecid. Probenecid (2.0 gm) reduced the 8‐hr urinary clearance and recovery of EACA by 50% without affecting plasma kinetics. Recovery of EACA in urine rose to 78% of the dose 48 hr after EACA. Plasma clearance of EACA did not differ from control EACA urinary clearance when 0.5 gm probenecid was given with EACA. In both cases all the EACA dose was recovered in urine within 8 hr. Clinical Pharmacology and Therapeutics (1980) 28, 223–228; doi:

Original language	English (US)
Pages (from-to)	223-228
Number of pages	6
Journal	Clinical Pharmacology & Therapeutics
Volume	28
Issue number	2
DOIs	https://doi.org/10.1038/clpt.1980.154
State	Published - Aug 1980

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)

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10.1038/clpt.1980.154

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title = "Effect of probenecid on the kinetics of epsilon‐aminocaproic acid",

abstract = "Healthy male subjects received, 1 wk apart, single oral doses of epsilon‐aminocaproic acid (EACA) 100 mg/kg alone, EACA with probenecid (0.5 gm), or EACA 2 hr after 2.0 gm probenecid. Probenecid (2.0 gm) reduced the 8‐hr urinary clearance and recovery of EACA by 50% without affecting plasma kinetics. Recovery of EACA in urine rose to 78% of the dose 48 hr after EACA. Plasma clearance of EACA did not differ from control EACA urinary clearance when 0.5 gm probenecid was given with EACA. In both cases all the EACA dose was recovered in urine within 8 hr. Clinical Pharmacology and Therapeutics (1980) 28, 223–228; doi:",

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AU - Dvorchik, Barry H.

AU - Katlic, Kerry L.

AU - Hayes, Arthur H.

AU - Eyster, M. Elaine

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N2 - Healthy male subjects received, 1 wk apart, single oral doses of epsilon‐aminocaproic acid (EACA) 100 mg/kg alone, EACA with probenecid (0.5 gm), or EACA 2 hr after 2.0 gm probenecid. Probenecid (2.0 gm) reduced the 8‐hr urinary clearance and recovery of EACA by 50% without affecting plasma kinetics. Recovery of EACA in urine rose to 78% of the dose 48 hr after EACA. Plasma clearance of EACA did not differ from control EACA urinary clearance when 0.5 gm probenecid was given with EACA. In both cases all the EACA dose was recovered in urine within 8 hr. Clinical Pharmacology and Therapeutics (1980) 28, 223–228; doi:

AB - Healthy male subjects received, 1 wk apart, single oral doses of epsilon‐aminocaproic acid (EACA) 100 mg/kg alone, EACA with probenecid (0.5 gm), or EACA 2 hr after 2.0 gm probenecid. Probenecid (2.0 gm) reduced the 8‐hr urinary clearance and recovery of EACA by 50% without affecting plasma kinetics. Recovery of EACA in urine rose to 78% of the dose 48 hr after EACA. Plasma clearance of EACA did not differ from control EACA urinary clearance when 0.5 gm probenecid was given with EACA. In both cases all the EACA dose was recovered in urine within 8 hr. Clinical Pharmacology and Therapeutics (1980) 28, 223–228; doi:

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Effect of probenecid on the kinetics of epsilon‐aminocaproic acid

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