TY - JOUR
T1 - Effect of Splenectomy on T Lymphocyte Subsets in Patients Infected with the Human Immunodeficiency Virus
AU - Zurlo, John J.
AU - Wood, Lauren
AU - Gaglione, Margaret Mackrell
AU - Polis, Michael A.
N1 - Funding Information:
From the Milton S. Hershey Medical Center, Hershey, Pennsylvania; and the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
PY - 1995/4
Y1 - 1995/4
N2 - A case-control study was conducted at two institutions to determine whether the absolute CD4 lymphocyte count or the percentage of lymphocytes bearing the CD4 marker (i.e., the CD4 percentage) is a more accurate indicator of underlying immune status in splenectomized patients infected with human immunodeficiency virus (HIV). Each of nine splenectomized HIV-infected cases was matched with six nonsplenectomized HIV-infected controlsthree matched for CD4 lymphocyte count and three for CD4 percentage. In analyses including the eight cases with an initial CD4 lymphocyte count of >200/mm3, controlling for the CD4 count revealed differences between cases and controls in terms of CD4 percentage (range, 10%–41% and 17%–54%, respectively; P <.01) and Centers for Disease Control and Prevention (CDC) clinical stage (P =.06). Controlling for the CD4 percentage revealed a significant difference between cases and controls in terms of CD4 count (range, 396–1,040 and 55–784 cells/mm3, respectively; P <.01) but not CDC clinical stage (P >.7). These data suggest that the numerical relationship between the CD4 lymphocyte count and the CD4 percentage among splenectomized HIV-infected patients with more than 200 CD4 cells/mm3 differs from that among nonsplenectomized patients. The CD4 percentage appears to be a more accurate indicator of the underlying level of immune function in the former group of patients.
AB - A case-control study was conducted at two institutions to determine whether the absolute CD4 lymphocyte count or the percentage of lymphocytes bearing the CD4 marker (i.e., the CD4 percentage) is a more accurate indicator of underlying immune status in splenectomized patients infected with human immunodeficiency virus (HIV). Each of nine splenectomized HIV-infected cases was matched with six nonsplenectomized HIV-infected controlsthree matched for CD4 lymphocyte count and three for CD4 percentage. In analyses including the eight cases with an initial CD4 lymphocyte count of >200/mm3, controlling for the CD4 count revealed differences between cases and controls in terms of CD4 percentage (range, 10%–41% and 17%–54%, respectively; P <.01) and Centers for Disease Control and Prevention (CDC) clinical stage (P =.06). Controlling for the CD4 percentage revealed a significant difference between cases and controls in terms of CD4 count (range, 396–1,040 and 55–784 cells/mm3, respectively; P <.01) but not CDC clinical stage (P >.7). These data suggest that the numerical relationship between the CD4 lymphocyte count and the CD4 percentage among splenectomized HIV-infected patients with more than 200 CD4 cells/mm3 differs from that among nonsplenectomized patients. The CD4 percentage appears to be a more accurate indicator of the underlying level of immune function in the former group of patients.
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U2 - 10.1093/clinids/20.4.768
DO - 10.1093/clinids/20.4.768
M3 - Article
C2 - 7795071
AN - SCOPUS:0028945289
SN - 1058-4838
VL - 20
SP - 768
EP - 771
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 4
ER -