@article{450fce91675d443bbdccb51143bdd7ef,
title = "Effect of surface treatment on diffusion and domain formation in supported lipid bilayers",
abstract = "Supported lipid bilayers are widely used as model systems due to their robustness. Due to the solid support, the properties of supported lipid bilayers are different from those of freestanding bilayers. In this article, we examine whether different surface treatments affect the properties of supported lipid bilayers. It will be shown that depending on the treatment method, the diffusion of the lipids can be adjusted approximately threefold without altering the composition. Additionally, as the bilayer-support interaction decreases, it becomes easier to form coexisting liquid-ordered and liquid-disordered domains. The physical/chemical alterations that result from the different treatment methods will be discussed.",
author = "Seu, {Kalani J.} and Pandey, {Anjan P.} and Farzin Haque and Proctor, {Elizabeth A.} and Ribbe, {Alexander E.} and Hovis, {Jennifer S.}",
note = "Funding Information: The effects that several different treatment methods have on supported bilayer properties were examined. Over the range of treatments—baking, detergent-only, and piranha etching—the lipid diffusion was observed to change approximately threefold. This change in diffusion coefficient was independent of composition, as the lipid mixture was held constant. The fastest diffusion was observed on the surfaces that were etched for 5 min. These surfaces also gave the lowest frictional coefficient. It was also observed that the surfaces that gave rise to the fastest diffusion also gave rise to the greatest probability of observing liquid-ordered domains. The authors thank Dr. D. Zemlyanov of the Surface Analysis Laboratory, Birck Nanotechnology Center, Purdue University, for assistance with the x-ray photoelectron spectroscopy experiments. J.S.H. is a recipient of a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund. ",
year = "2007",
month = apr,
doi = "10.1529/biophysj.106.099721",
language = "English (US)",
volume = "92",
pages = "2445--2450",
journal = "Biophysical journal",
issn = "0006-3495",
publisher = "Elsevier B.V.",
number = "7",
}