TY - JOUR
T1 - Effect of transcatheter aortic valve implantation on health-related quality of life in older adults with multimorbidity
AU - Kamenskaya, Oksana
AU - Loginova, Irina
AU - Kretov, Evgeniy
AU - Prokhorikhin, Alexey
AU - Tarkova, Alexandra
AU - Lomivorotov, Vladimir V.
AU - Karaskov, Alexander
N1 - Funding Information:
This work was supported by a Russian Science Foundation grant (№ 17-75-30009 ). The funding source had no involvement in the development of the research project, in the collection, analysis and interpretation of data, and in the decision to submit an article for publication.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose: The purpose of this study was to determine the effect of transcatheter aortic valve implantation on health-related quality of life in older adults with multimorbidity and to evaluate the predictive factors for postoperative quality of life impairment in such patients. Material and method: This study included 141 older adults with severe aortic stenosis scheduled for elective transcatheter aortic valve implantation. Quality of life was examined in all patients using the Short-Form 36 Health Survey Questionnaire, before and 2 years after surgery. Comorbidity was assessed using the Charlson Comorbidity Index. Results: In older adult patients with aortic stenosis and multimorbidity, transcatheter aortic valve implantation significantly improved both physical and mental components of quality of life 2 years after surgery. A Charlson Comorbidity Index ≥5 points was independently associated with the absence of positive dynamics in Physical Health score [odds ratio (OR) 0.38 (0.20–0.75), p = 0.007]. Charlson Comorbidity Index ≥5 points [OR 0.31 (0.19–0.58), p = 0.026] and new-onset arrhythmia [OR 0.54 (0.38–0.78), p = 0.017] were independent predictors of the absence of positive dynamics in Mental Health score after transcatheter aortic valve implantation. Conclusions: High-level comorbidity (Charlson Comorbidity Index ≥5 points) predicts both Physical and Mental Health scores for quality of life impairment following transcatheter aortic valve implantation in older adults, and new-onset arrhythmia predicts the Mental Health score for quality of life impairment following transcatheter aortic valve implantation in these patients.
AB - Purpose: The purpose of this study was to determine the effect of transcatheter aortic valve implantation on health-related quality of life in older adults with multimorbidity and to evaluate the predictive factors for postoperative quality of life impairment in such patients. Material and method: This study included 141 older adults with severe aortic stenosis scheduled for elective transcatheter aortic valve implantation. Quality of life was examined in all patients using the Short-Form 36 Health Survey Questionnaire, before and 2 years after surgery. Comorbidity was assessed using the Charlson Comorbidity Index. Results: In older adult patients with aortic stenosis and multimorbidity, transcatheter aortic valve implantation significantly improved both physical and mental components of quality of life 2 years after surgery. A Charlson Comorbidity Index ≥5 points was independently associated with the absence of positive dynamics in Physical Health score [odds ratio (OR) 0.38 (0.20–0.75), p = 0.007]. Charlson Comorbidity Index ≥5 points [OR 0.31 (0.19–0.58), p = 0.026] and new-onset arrhythmia [OR 0.54 (0.38–0.78), p = 0.017] were independent predictors of the absence of positive dynamics in Mental Health score after transcatheter aortic valve implantation. Conclusions: High-level comorbidity (Charlson Comorbidity Index ≥5 points) predicts both Physical and Mental Health scores for quality of life impairment following transcatheter aortic valve implantation in older adults, and new-onset arrhythmia predicts the Mental Health score for quality of life impairment following transcatheter aortic valve implantation in these patients.
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U2 - 10.1016/j.archger.2018.10.007
DO - 10.1016/j.archger.2018.10.007
M3 - Article
C2 - 30390428
AN - SCOPUS:85055742086
SN - 0167-4943
VL - 80
SP - 76
EP - 81
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
ER -
