Substituents placed on the phenyl rings of 2,3-diphenyl-1,3-thiazolidin-4-one affect the electron density surrounding both the methine proton and the C(2) carbon. These changes are reflected in the differing chemical shifts for these atoms relative to the parent compound. The other carbons in the heterocyclic ring appear to be similarly affected by substituents on the phenyl rings. Correlations for the effects of various substituents in both the 2-and 3-phenyl rings with the 1H and 13C chemical shifts for the aforementioned sites are discussed using both Hammett and Swain-Lupton dual parameter methods. A conformational analysis using ab initio calculations is in agreement with the observed NMR data.
|Number of pages
|Magnetic Resonance in Chemistry
|Published - Aug 1996
All Science Journal Classification (ASJC) codes
- General Chemistry
- General Materials Science