TY - JOUR
T1 - Effects of acetaminophen and ibuprofen on renal function in the stressed kidney
AU - Farquhar, W. B.
AU - Morgan, A. L.
AU - Zambraski, E. J.
AU - Kenney, W. L.
PY - 1999/2
Y1 - 1999/2
N2 - Exercise, salt restriction, and/or dehydration causes transient reductions in renal function that may be buffered by vasodilatory prostaglandins (PGs). Over-the-counter (OTC) analgesics have the potential to alter renal hemodynamics by inhibiting renal PGs. Therefore, we tested the renal effects of the maximal recommended dose of acetaminophen (Acet, 4 g/day) and ibuprofen (Ibu, 1.2 g/day) vs. a placebo (Pl) in humans subjected to progressive renal stresses. After baseline measurements, 12 fit young (25 ± 1 yr) men and women underwent 3 days of a low (10 meq/day)-sodium diet while taking one of the drugs or Pl (crossover design). Day 4 involved dehydration (- 1.6% body wt) followed by 45 min of treadmill exercise (65% maximal O2 uptake) in the heat (36°C). These combined stressors caused dramatic decreases in effective renal plasma flow, glomerular filtration rate (GFR), and sodium excretion. Baseline GFR (range: 118-123 ml/min) decreased to 78 ± 4, 73 ± 5, and 82 ± 5 ml/min postexercise in the Acer, Ibu, and Pl trials, respectively, with a significantly greater decrease in GFR in the Ibu trial (P < 0.05 vs. Pl). OTC Ibu has small but statistically significant effects on GFR during exercise in a sodium- and volume-depleted state; OTC Acet was associated with no such effects.
AB - Exercise, salt restriction, and/or dehydration causes transient reductions in renal function that may be buffered by vasodilatory prostaglandins (PGs). Over-the-counter (OTC) analgesics have the potential to alter renal hemodynamics by inhibiting renal PGs. Therefore, we tested the renal effects of the maximal recommended dose of acetaminophen (Acet, 4 g/day) and ibuprofen (Ibu, 1.2 g/day) vs. a placebo (Pl) in humans subjected to progressive renal stresses. After baseline measurements, 12 fit young (25 ± 1 yr) men and women underwent 3 days of a low (10 meq/day)-sodium diet while taking one of the drugs or Pl (crossover design). Day 4 involved dehydration (- 1.6% body wt) followed by 45 min of treadmill exercise (65% maximal O2 uptake) in the heat (36°C). These combined stressors caused dramatic decreases in effective renal plasma flow, glomerular filtration rate (GFR), and sodium excretion. Baseline GFR (range: 118-123 ml/min) decreased to 78 ± 4, 73 ± 5, and 82 ± 5 ml/min postexercise in the Acer, Ibu, and Pl trials, respectively, with a significantly greater decrease in GFR in the Ibu trial (P < 0.05 vs. Pl). OTC Ibu has small but statistically significant effects on GFR during exercise in a sodium- and volume-depleted state; OTC Acet was associated with no such effects.
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U2 - 10.1152/jappl.1999.86.2.598
DO - 10.1152/jappl.1999.86.2.598
M3 - Article
C2 - 9931196
AN - SCOPUS:0033055824
SN - 8750-7587
VL - 86
SP - 598
EP - 604
JO - Journal of applied physiology
JF - Journal of applied physiology
IS - 2
ER -