TY - JOUR
T1 - Effects of atorvastatin on vascular function, inflammation, and androgens in women with polycystic ovary syndrome
T2 - A double-blind, randomized, placebo-controlled trial
AU - Raja-Khan, Nazia
AU - Kunselman, Allen
AU - Hogeman, Cynthia S.
AU - Stetter, Christy M.
AU - Demers, Laurence
AU - Legro, Richard
PY - 2011/4
Y1 - 2011/4
N2 - To determine the effects of statins on vascular function, inflammation, and androgen levels in women with polycystic ovary syndrome (PCOS), we randomized 20 women with PCOS who had low-density lipoprotein cholesterol levels >100 mg/dL to atorvastatin (40 mg/day) or placebo for 6 weeks and found that atorvastatin reduced androgen levels, biomarkers of inflammation, and blood pressure; increased insulin levels and brachial artery conductance during reactive hyperemia; and failed to improve brachial artery flow-mediated dilation. We conclude that until additional studies demonstrate a clear risk-to-benefit ratio favoring statin therapy in PCOS, statins should only be used in women with PCOS who meet current indications for statin treatment.
AB - To determine the effects of statins on vascular function, inflammation, and androgen levels in women with polycystic ovary syndrome (PCOS), we randomized 20 women with PCOS who had low-density lipoprotein cholesterol levels >100 mg/dL to atorvastatin (40 mg/day) or placebo for 6 weeks and found that atorvastatin reduced androgen levels, biomarkers of inflammation, and blood pressure; increased insulin levels and brachial artery conductance during reactive hyperemia; and failed to improve brachial artery flow-mediated dilation. We conclude that until additional studies demonstrate a clear risk-to-benefit ratio favoring statin therapy in PCOS, statins should only be used in women with PCOS who meet current indications for statin treatment.
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U2 - 10.1016/j.fertnstert.2010.11.040
DO - 10.1016/j.fertnstert.2010.11.040
M3 - Article
C2 - 21144505
AN - SCOPUS:79952992901
SN - 0015-0282
VL - 95
SP - 1849
EP - 1852
JO - Fertility and sterility
JF - Fertility and sterility
IS - 5
ER -