TY - JOUR
T1 - Effects of cholecystokinin, d-amphetamine and fenfluramine in rats trained to discriminate 3 from 22 hr food deprivation
AU - Corwin, R. L.
AU - Woolverton, W. L.
AU - Schuster, C. R.
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1990
Y1 - 1990
N2 - Attempts to assess similarities between the interoceptive stimuli of anorectic drugs and food satiation have generally been limited to human verbal reports. The purpose of the present study was to develop a procedure for assessing similarities between the interoceptive stimuli of food in the gut and various drugs known to alter food intake in rats. Rats (n = 23) were trained in a two-lever, food-reinforced, discrimination paradigm to press one lever when deprived of food for 3 hr and another lever when deprived of food for 22 hr. Criteria for stimulus control over responding were achieved after a mean of 92 (range = 26-175) training sessions. In time course tests, rats were tested when 22, 12, 6 and 3 hr food-deprived. As the number of hours of food deprivation decreased, the percentage of responses that occurred on the 3-hr food deprivation lever increased. In substitution tests, rats that were 22-hr food-deprived consistently responded as if they were 3-hr food deprived after administration of sweetened condensed milk preloads or cholecystokinin, but only occasionally after administration of water preloads. LiCl, d-amphetamine or fenfluramine. These results demonstrate that the presence of food in the gut can function as a discriminative stimulus to control lever choice in rats. Furthermore, they suggest that the discriminative stimulus effects of cholecystokinin, but not d-amphetamine or fenfluramine, are similar to those of food in the gut, and support the hypothesis that cholecystokinin plays a role in the regulation of food intake.
AB - Attempts to assess similarities between the interoceptive stimuli of anorectic drugs and food satiation have generally been limited to human verbal reports. The purpose of the present study was to develop a procedure for assessing similarities between the interoceptive stimuli of food in the gut and various drugs known to alter food intake in rats. Rats (n = 23) were trained in a two-lever, food-reinforced, discrimination paradigm to press one lever when deprived of food for 3 hr and another lever when deprived of food for 22 hr. Criteria for stimulus control over responding were achieved after a mean of 92 (range = 26-175) training sessions. In time course tests, rats were tested when 22, 12, 6 and 3 hr food-deprived. As the number of hours of food deprivation decreased, the percentage of responses that occurred on the 3-hr food deprivation lever increased. In substitution tests, rats that were 22-hr food-deprived consistently responded as if they were 3-hr food deprived after administration of sweetened condensed milk preloads or cholecystokinin, but only occasionally after administration of water preloads. LiCl, d-amphetamine or fenfluramine. These results demonstrate that the presence of food in the gut can function as a discriminative stimulus to control lever choice in rats. Furthermore, they suggest that the discriminative stimulus effects of cholecystokinin, but not d-amphetamine or fenfluramine, are similar to those of food in the gut, and support the hypothesis that cholecystokinin plays a role in the regulation of food intake.
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M3 - Article
C2 - 2338655
AN - SCOPUS:0025354563
SN - 0022-3565
VL - 253
SP - 720
EP - 728
JO - Journal of Pharmacology and Experimental Therapeutics
JF - Journal of Pharmacology and Experimental Therapeutics
IS - 2
ER -